Ichas F, Jouaville L S, Sidash S S, Mazat J P, Holmuhamedov E L
Groupe d'Etude des Systèmes Biologiques Intégrés, D(BM)2, Universitè Bordeaux II, France.
FEBS Lett. 1994 Jul 11;348(2):211-5. doi: 10.1016/0014-5793(94)00615-6.
We report reversible Ca(2+)-induced Ca2+ release from mitochondria, which takes the form of Ca2+ spikes. Mitochondrial Ca2+ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca2+ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated--in a threshold-dependent manner--with inositol-triphosphate-mediated Ca2+ responses on permeabilized cells. Evidence that mitochondrial Ca(2+)-induced Ca2+ release contributes to inositol-triphosphate-mediated Ca2+ responses in intact cells is also reported.
我们报告了线粒体中可逆的Ca(2+)诱导的Ca2+释放，其形式为Ca2+尖峰。线粒体Ca2+尖峰是一种全或无的过程，其阈值依赖于用作刺激的Ca2+脉冲的频率和幅度。这种尖峰依赖于线粒体通透性转换孔的瞬时运作，并以阈值依赖的方式，由通透细胞上肌醇三磷酸介导的Ca2+反应引发。本文还报道了线粒体Ca(2+)诱导的Ca2+释放有助于完整细胞中肌醇三磷酸介导的Ca2+反应的证据。
