Nair L S, Nair A S
Indian J Malariol. 1993 Dec;30(4):207-14.
A study of the effects of malaria infection on the progress and outcome of pregnancy was carried out during 1987-88 in the Medical College Hospital, Surat, Gujarat. Pregnant women were highly susceptible to the infection (SPR, 57.7) compared to the general population (SPR, 18.6). P. falciparum infection was predominant (62.4%). The infection rate was also found to be higher (SPR, 72.2%) in second trimester compared to first and third semesters. Primigravidae seemed to be at a greater risk as the mean parasitaemia level was higher (39%) and the outcome poor as compared to multigravidae (29%). Infection during pregnancy caused severe maternal complications like abortion (9.7%), premature labour (59.6%), and still-births (5.7%), which were higher in P. falciparum infection. Microcytic anaemia combined with dimorphic anaemia was predominant in the infected group (89.5%). Cord blood in 4 cases and on baby's blood were found positive for malaria parasite, showing transplacental passage of malaria parasites, which is rare. The infection was found to have a definite bearing on the low birth weight of babies. Chemoprophylaxis could obviate much of the complications.
1987 - 1988年期间，在古吉拉特邦苏拉特市医学院医院开展了一项关于疟疾感染对妊娠进程及结局影响的研究。与普通人群（SPR为18.6）相比，孕妇对该感染高度易感（SPR为57.7）。恶性疟原虫感染占主导（62.4%）。与孕早期和孕晚期相比，孕中期的感染率也更高（SPR为72.2%）。初产妇似乎风险更大，因为其平均疟原虫血症水平更高（39%），且与经产妇（29%）相比结局较差。孕期感染会引发严重的母体并发症，如流产（9.7%）、早产（59.6%）和死产（5.7%），在恶性疟原虫感染中这些并发症发生率更高。感染组以小细胞性贫血合并双形性贫血为主（89.5%）。在4例病例的脐带血以及婴儿血液中发现疟原虫呈阳性，表明疟原虫可经胎盘传播，这种情况较为罕见。研究发现该感染与婴儿低出生体重有明确关联。化学预防可避免许多并发症。
