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一些常见非淋巴细胞肿瘤和培养细胞系在植物血凝素和异种抗红细胞抗血清作用下的细胞毒性效应潜力。

The cytotoxic effector potential of some common non-lymphoid tumors and cultured cell lines with phytohemagglutinin and heterologous anti-erythrocyte antisera.

作者信息

Muchmore A V, Nelson D L, Blaese R M

出版信息

J Immunol. 1975 Mar;114(3):1001-3.

PMID:803533
Abstract

We have found that a) phytohemagglutinin can induce red blood cell cytolysis by non-lymphoid tumors and cell lines, b) rabbit anti-chicken red blood cell antibody but not turkey anti-chicken red blood cell antibody can mediate an antibody-directed cellular cytotoxicity type of cytotoxicity utilizing P815Y mastocytoma cells or rat embryo fibroblasts as effectors, and c) none of these cell line effectors was capable of killing metabolically active cultured cell line targets in the presence of phytohemagglutinin.

摘要

我们发现

a）植物血凝素可诱导非淋巴细胞肿瘤和细胞系引起红细胞溶解；b）兔抗鸡红细胞抗体而非火鸡抗鸡红细胞抗体，可利用P815Y肥大细胞瘤细胞或大鼠胚胎成纤维细胞作为效应细胞，介导抗体导向细胞毒性类型的细胞毒性作用；c）在存在植物血凝素的情况下，这些细胞系效应细胞均无法杀死代谢活跃的培养细胞系靶标。

相似文献

1
The cytotoxic effector potential of some common non-lymphoid tumors and cultured cell lines with phytohemagglutinin and heterologous anti-erythrocyte antisera.一些常见非淋巴细胞肿瘤和培养细胞系在植物血凝素和异种抗红细胞抗血清作用下的细胞毒性效应潜力。
J Immunol. 1975 Mar;114(3):1001-3.
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引用本文的文献

1
Lectin-dependent neutrophil-mediated cytotoxicity. I. Characteristics.凝集素依赖性中性粒细胞介导的细胞毒性。I. 特征
Immunology. 1976 Aug;31(2):303-11.
2
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.短小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响。一项为期28天的序贯研究。II. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性及迟发型超敏皮肤反应的变化。
Clin Exp Immunol. 1979 Feb;35(2):171-9.
3
Contribution of lymphocytes bearing Fcgamma receptors to PHA-induced cytotoxicity.
携带Fcγ受体的淋巴细胞对PHA诱导的细胞毒性的作用。
Immunology. 1978 Jul;35(1):49-56.