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[通过电泳迁移率测定结核病患者及临床登记册IIIA组患者淋巴细胞的功能活性]

[Determination of functional activity of lymphocytes in patients with tuberculosis and in patients of group IIIA of clinic registries by electrophoretic mobility].

作者信息

Morozova T I, Khudzik L B, Tikhomirova L A

出版信息

Probl Tuberk. 1994(2):40-2.

PMID:8036219
Abstract

The electrophoretic mobility of peripheral blood lymphocytes was studied in 35 patients with pulmonary tuberculosis, 128 persons clinically cured of tuberculosis, and 30 healthy persons by using an Elphor-VaP-5 apparatus (Germany). This study revealed abnormal lymphocytic functional activity both in patients with tuberculosis and in patients with great residual changes after prior tuberculosis, which was the basis for using of thymic immunomodulators (thymalin or thymogen) in the latters. Immunomodulators improved the tolerance of antirecurrent chemotherapy in persons with IIIA dispensary register group and produced a marked stimulating effect on the functional activity of T and B lymphocytes.

摘要

使用德国的Elphor-VaP-5仪器,对35例肺结核患者、128例临床治愈的结核病患者和30名健康人外周血淋巴细胞的电泳迁移率进行了研究。该研究揭示,结核病患者以及既往患结核病后有大量残留病变的患者,均存在淋巴细胞功能活动异常,这是对后者使用胸腺免疫调节剂(胸腺素或胸腺生成素)的依据。免疫调节剂提高了处于ⅢA类预防登记组人群对抗复发化疗的耐受性,并对T淋巴细胞和B淋巴细胞的功能活动产生显著刺激作用。

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