Podgaĭnaia E A
Lik Sprava. 1993 Jul(8):83-5.
In vitro experiments established immunomodulatory effect of yeast-originated polysaccharide rodexamen. Functional state of lymphocytes and monocytes of peripheral blood before and after the contact with the drug was studied in 50 patients with pulmonary tuberculosis and in 20 healthy subjects. Effect of rodexamen on lymphocytes and monocytes was assessed by rosette-forming abilities and phagocytic activity respectively. The results demonstrated dependence of immunocorrective effect on the initial level of cell's functional activity and quantity of the drug.
体外实验证实了酵母源多糖罗地昔明的免疫调节作用。对50例肺结核患者和20名健康受试者研究了其外周血淋巴细胞和单核细胞在接触该药物前后的功能状态。分别通过花环形成能力和吞噬活性评估罗地昔明对淋巴细胞和单核细胞的作用。结果表明免疫纠正作用取决于细胞功能活性的初始水平和药物剂量。