Sato T
Shizugawa Public General Hospital, Miyagi, Japan.
Tohoku J Exp Med. 1994 Jan;172(1):39-49. doi: 10.1620/tjem.172.39.
Fourteen Male Wistar rats were orally administered 20% ethanol ad libitum in place of water. After 1, 2, 3, 6 and 12 months of ethanol ingestion, the gap junctions of pancreatic acinar and ductal cells were observed by transparent electron microscopy. The result was compared with fifteen control animals. In the control, the ductal cells proved to have only small sized (0.1 micron in length) gap junction located in the apical domain as a part of junctional complex. While, in the acinar cells, not only small but large-sized gap junctions several microns in length were observed in the baso-lateral domain. After 3 months of ethanol ingestion, the gap of these two types of gap junctions was replaced with a continuous, granular structure. In addition, irregularly running gap junctions were observed after 6 months of ethanol ingestion. The functional implication of these morphological changes is not clear.
十四只雄性Wistar大鼠被随意给予20%乙醇以替代水。在摄入乙醇1、2、3、6和12个月后，通过透射电子显微镜观察胰腺腺泡细胞和导管细胞的缝隙连接。将结果与十五只对照动物进行比较。在对照组中，导管细胞仅在顶端区域有作为连接复合体一部分的小尺寸（长度为0.1微米）缝隙连接。而在腺泡细胞中，在基底外侧区域不仅观察到小尺寸缝隙连接，还观察到长度达数微米的大尺寸缝隙连接。摄入乙醇3个月后，这两种类型缝隙连接的间隙被连续的颗粒状结构取代。此外，摄入乙醇6个月后观察到不规则分布的缝隙连接。这些形态学变化的功能意义尚不清楚。
