Dye C
Isaac Newton Institute for Mathematical Sciences, Cambridge, UK.
Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):147-9. doi: 10.1016/0035-9203(94)90270-4.
This paper discusses 2 prominent, contemporary issues in the epidemiological context of insect vector control: (i) the magnitude of the control problem, and (ii) non-linear processes influencing vector control. It concludes that we still cannot reliably measure the scale of some important control problems; e.g., there is considerable uncertainty about the basic reproduction number of malaria. The emergence of new concepts such as strain-specific immunity, and a growing emphasis on disease control as distinct from infection control, mean that some quantitative problems are being redefined more quickly than they are being solved. Population biologists have urged exploration of density-dependent processes which may help or hinder new methods of vector control. This brief review of non-linear phenomena such as facilitation and limitation finds little evidence that they will significantly influence, e.g., the introduction of some novel refractory mechanism into a vector population.
（i）控制问题的规模，以及（ii）影响病媒控制的非线性过程。结论是，我们仍然无法可靠地衡量一些重要控制问题的规模；例如，疟疾的基本繁殖数存在相当大的不确定性。诸如菌株特异性免疫等新概念的出现，以及对疾病控制（与感染控制不同）的日益重视，意味着一些定量问题的重新定义速度比解决速度更快。种群生物学家敦促探索可能有助于或阻碍病媒控制新方法的密度依赖过程。对促进和限制等非线性现象的简要回顾发现，几乎没有证据表明它们会显著影响，例如，将一些新型抗性机制引入病媒种群。
