用于治疗实验性皮肤利什曼病的氨基糖苷类药膏。
Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis.
作者信息
Neal R A, Murphy A G, Olliaro P, Croft S L
机构信息
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
出版信息
Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):223-5. doi: 10.1016/0035-9203(94)90307-7.
A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective. The ointment containing urea was non-irritant to mice, whereas ointments containing quaternary ammonium compounds were irritant. The 15% AS/10% urea/WSP ointment was not effective in the treatment of L. mexicana or L. panamensis lesions on Balb/C mice, no cure being observed.
一种含15%硫酸氨基糖苷（AS）/10%尿素/白软石蜡（WSP）的软膏，在对Balb/C小鼠进行局部涂抹10天后，治愈了所有的硕大利什曼原虫损伤。治疗10周后观察到一些复发情况。单独的AS加在WSP软膏中也非常有效。含尿素的软膏对小鼠无刺激性，而含季铵化合物的软膏有刺激性。15% AS/10%尿素/WSP软膏对Balb/C小鼠的墨西哥利什曼原虫或巴拿马利什曼原虫损伤治疗无效，未观察到治愈情况。
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