Nalbanski B, Novachkov V, Rachev E, Nikolov A, Stoianov S, Katsarova M, Maleeva A
Akush Ginekol (Sofiia). 1993;32(3):69-70.
By means of the serum level of estradiol and the vaginal smear indexes the antigonadotropic activity of the preparation Danoval (2-3-isoxasol-17-ethinyltestosterone) is indirectly evaluated on 15 infertility patients with laparoscopic proved endometriosis. After 5 month's course of treatment with 400 mg daily the level of estradiol decreased from 1.54 to 0.31 nmol/l, IA from 20.8 to 10.4 and IP from 32 to 17.3. The side effects are slight and descend from the pharmacological properties of the preparation. Two patients became pregnant in three months after the treatment.
通过检测雌二醇血清水平和阴道涂片指数，对15例经腹腔镜证实患有子宫内膜异位症的不孕患者间接评估了药物Danoval（2-3-异恶唑-17-乙炔睾酮）的抗促性腺活性。在每日服用400mg、为期5个月的疗程后，雌二醇水平从1.54降至0.31nmol/L，IA从20.8降至10.4，IP从32降至17.3。副作用轻微，源于该药物的药理特性。两名患者在治疗后三个月内怀孕。
