Zhang J, Olshan A, Cai W W
Carolina Population Center, University of North Carolina at Chapel Hill.
Epidemiology. 1994 May;5(3):341-4. doi: 10.1097/00001648-199405000-00014.
The evidence for the association between threatened abortion and birth defects is limited and inconsistent. This study examined this relation using data from the Shanghai Birth Defects Monitoring Program. A total of 1,013 cases of birth defects and an equal number of controls were analyzed. Our study showed that women with threatened abortion had a 50% higher risk of having a baby with birth defects compared with those without this complication, controlling for other factors (adjusted odds ratio = 1.5; 95% confidence interval = 1.1-2.1). Threatened abortion was generally related to defects of the urogenital system, heart and circulatory system, and musculoskeleton and limbs and was specifically associated with polydactyly, undescended testicle, and hypospadias.
先兆流产与出生缺陷之间关联的证据有限且不一致。本研究利用上海出生缺陷监测项目的数据对这种关系进行了调查。共分析了1013例出生缺陷病例及数量相等的对照组。我们的研究表明，在控制其他因素后，有先兆流产的女性生出有出生缺陷婴儿的风险比没有这种并发症的女性高50%（调整后的优势比=1.5；95%置信区间=1.1-2.1）。先兆流产一般与泌尿生殖系统、心脏和循环系统以及肌肉骨骼和四肢的缺陷有关，尤其与多指畸形、隐睾和尿道下裂有关。
