Brenner S, Wolf R, Ophir J
Department of Dermatology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 1):210-2. doi: 10.1016/s0190-9622(94)70148-2.
Eosinophilic pustular folliculitis (EPF) was initially defined as a sterile folliculitis of unknown cause. Because attempts to demonstrate bacterial organisms have been unsuccessful, and antibiotic therapy is usually ineffective, a bacterial infection is not considered a plausible causative factor for this disease.
Our purpose was to describe five patients with the clinical and histologic characteristics of EPF and to report the results of bacterial cultures.
Biopsy specimens were examined and pustules were cultured.
In three of the five patients, Pseudomonas infection of the hair follicle was the cause of the disease as proven by repeated cultures and the response to specific therapy. Three patients had a systemic disorder known to cause immunologic alteration: AIDS in one and a myeloproliferative disorder in two.
Although EPF was initially defined as a sterile folliculitis of unknown origin, three of our patients had an identifiable and treatable cause. We believe that these cases warrant the diagnosis of EPF.
嗜酸性脓疱性毛囊炎（EPF）最初被定义为一种病因不明的无菌性毛囊炎。由于试图证明存在细菌病原体的尝试均未成功，且抗生素治疗通常无效，因此细菌感染不被认为是该疾病可能的致病因素。
我们的目的是描述5例具有EPF临床和组织学特征的患者，并报告细菌培养结果。
对活检标本进行检查，并对脓疱进行培养。
5例患者中有3例，经反复培养及对特定治疗的反应证实，毛囊假单胞菌感染是该病的病因。3例患者患有已知会引起免疫改变的全身性疾病：1例为艾滋病，2例为骨髓增殖性疾病。
尽管EPF最初被定义为一种病因不明的无菌性毛囊炎，但我们的3例患者有可识别且可治疗的病因。我们认为这些病例符合EPF的诊断。
