Barrios N J, Kiernan M, Beckerman R, Davis S
Department of Pediatrics, All Children's Hospital, St Petersburg, Florida 33701.
J Natl Med Assoc. 1994 Apr;86(4):270-2.
Patients with cystic fibrosis (CF) suffer from severe chronic pulmonary infections but rarely develop bacteremia/septicemia suggestive of an intact splenic mononuclear phagocyte function. The splenic function of 25 patients diagnosed with CF, aged 2 to 37 years, was evaluated using erythrocyte pit count by direct interference contrast microscopy. Results were compared with patients with sickle cell disease and normal individuals. All CF patients displayed normal splenic function by pit count. The mean percentage of pitted erythrocytes was 0.20 +/- 0.28 (range: 0.0% to 1.0%) versus 0.19 +/- 0.33 (range: 0.0% to 1.4%) in normal eusplenic controls. There were no episodes of bacteremia or septicemia despite recurrent acute exacerbations of chronic bacterial bronchitis and the use of central lines. We conclude that splenic function in CF is unabridged and may account for the rarity of bacteremia/septicemia in patients with CF despite the high prevalence of chronic bronchial infection in this population.
囊性纤维化（CF）患者患有严重的慢性肺部感染，但很少发生提示脾单核吞噬细胞功能完整的菌血症/败血症。采用直接干涉对比显微镜红细胞凹陷计数法，对25例年龄在2至37岁、诊断为CF的患者的脾功能进行了评估。将结果与镰状细胞病患者和正常个体进行比较。通过凹陷计数，所有CF患者均显示脾功能正常。凹陷红细胞的平均百分比为0.20±0.28（范围：0.0%至1.0%），而正常脾功能对照者为0.19±0.33（范围：0.0%至1.4%）。尽管慢性细菌性支气管炎反复急性加重且使用了中心静脉导管，但未发生菌血症或败血症。我们得出结论，CF患者的脾功能未受损害，这可能解释了尽管该人群慢性支气管感染患病率很高，但CF患者菌血症/败血症罕见的原因。
