对细菌的细胞免疫：囊性纤维化患者体外淋巴细胞对铜绿假单胞菌反应的受损情况。
Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.
作者信息
Sorensen R U, Stern R C, Polmar S H
出版信息
Infect Immun. 1977 Dec;18(3):735-40. doi: 10.1128/iai.18.3.735-740.1977.
Abstract
Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A and to Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa were evaluated in patients with cystic fibrosis and in normal individuals. Lymphocyte proliferation in vitro was stimulated by gentamicin-killed whole bacteria, and the proliferative response was measured by [3H]thymidine incorporation. The in vitro lymphocyte responses to antibiotic-killed bacterial reached maximum thymidine incorporation after 5 days in culture and followed a unimodal dose-response curve for each of the bacteria studied. A significant specific incapacity to respond to P. aeruginosa was detected in cystic fibrosis patients with advanced clinical disease.
摘要
在囊性纤维化患者和正常个体中评估了淋巴细胞对有丝分裂原植物血凝素和刀豆球蛋白A以及对化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌和铜绿假单胞菌的反应。用庆大霉素杀死的全菌刺激体外淋巴细胞增殖，并通过[3H]胸苷掺入来测量增殖反应。体外淋巴细胞对经抗生素杀死细菌的反应在培养5天后达到最大胸苷掺入量，并且对于所研究的每种细菌均呈现单峰剂量反应曲线。在患有晚期临床疾病的囊性纤维化患者中检测到对铜绿假单胞菌反应的显著特异性无能。
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A 5 YEAR CLINICAL EVALUATION OF A THERAPEUTIC PROGRAM FOR PATIENTS WITH CYSTIC FIBROSIS.一项针对囊性纤维化患者治疗方案的5年临床评估
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