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1
Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.对细菌的细胞免疫：囊性纤维化患者体外淋巴细胞对铜绿假单胞菌反应的受损情况。
Infect Immun. 1977 Dec;18(3):735-40. doi: 10.1128/iai.18.3.735-740.1977.
2
Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients.囊性纤维化患者对革兰氏阴性菌的细胞免疫缺陷。
Infect Immun. 1979 Feb;23(2):398-402. doi: 10.1128/iai.23.2.398-402.1979.
3
Changes in lymphocyte reactivity to Pseudomonas aeruginosa in hospitalized patients with cystic fibrosis.住院囊性纤维化患者对铜绿假单胞菌淋巴细胞反应性的变化。
Am Rev Respir Dis. 1981 Jan;123(1):37-41. doi: 10.1164/arrd.1981.123.1.37.
4
Lymphocyte responsiveness to Pseudomonas aeruginosa in cystic fibrosis: Relationship to status of pulmonary disease in sibling pairs.囊性纤维化患者淋巴细胞对铜绿假单胞菌的反应性：与同胞对中肺部疾病状况的关系。
J Pediatr. 1978 Aug;93(2):201-5. doi: 10.1016/s0022-3476(78)80496-x.
5
Influence of cystic fibrosis plasma on lymphocyte responses to Pseudomonas aeruginosa in vitro.囊性纤维化血浆对体外淋巴细胞对铜绿假单胞菌反应的影响。
Pediatr Res. 1981 Jan;15(1):14-8. doi: 10.1203/00006450-198101000-00004.
6
Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori.铜绿假单胞菌、幽门螺杆菌、空肠弯曲菌和流感嗜血杆菌共有的交叉反应性抗原可能导致幽门螺杆菌抗体滴度出现假阳性。
Clin Diagn Lab Immunol. 1995 Mar;2(2):149-55. doi: 10.1128/cdli.2.2.149-155.1995.
7
Suppression of in vitro lymphocyte DNA synthesis by killed Pseudomonas aeruginosa.死的铜绿假单胞菌对体外淋巴细胞DNA合成的抑制作用
Infect Immun. 1983 Feb;39(2):630-7. doi: 10.1128/iai.39.2.630-637.1983.
8
Lymphocyte responses of human neonates to bacterial antigens.人类新生儿对细菌抗原的淋巴细胞反应。
Cell Immunol. 1981 Jan 15;57(2):307-15. doi: 10.1016/0008-8749(81)90089-7.
9
Pseudomonas aeruginosa infection in cystic fibrosis. Relationship between mucoid strains of Pseudomonas aeruginosa and the humoral immune response.囊性纤维化中的铜绿假单胞菌感染。铜绿假单胞菌黏液型菌株与体液免疫反应之间的关系。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Aug;82(4):551-8.
10
Quantitative studies on immunologically specific and non-specific absorption of Pseudomonas aeruginosa antibodies in serum from cystic fibrosis patients.对囊性纤维化患者血清中铜绿假单胞菌抗体的免疫特异性和非特异性吸收的定量研究。
Acta Pathol Microbiol Scand C. 1981 Jun;89(3):185-92. doi: 10.1111/j.1699-0463.1981.tb02684.x.

引用本文的文献

1
Vaccines for Pseudomonas aeruginosa: a long and winding road.铜绿假单胞菌疫苗：一条漫长而曲折的道路。
Expert Rev Vaccines. 2014 Apr;13(4):507-19. doi: 10.1586/14760584.2014.890053. Epub 2014 Feb 27.
2
Lymphocytes in cystic fibrosis lung disease: a tale of two immunities.囊性纤维化肺病中的淋巴细胞：两种免疫的故事。
Clin Exp Immunol. 2004 Mar;135(3):358-60. doi: 10.1111/j.1365-2249.2003.02389.x.
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Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response.慢性铜绿假单胞菌肺部感染预后的改善与以Th1为主导的细胞因子反应的诱导有关。
Clin Exp Immunol. 2002 Feb;127(2):206-13. doi: 10.1046/j.1365-2249.2002.01731.x.
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Characterization of T cell clones derived from lymph nodes and lungs of Pseudomonas aeruginosa-susceptible and resistant mice following immunization with heat-killed bacteria.用热灭活细菌免疫后，对源自铜绿假单胞菌易感和抗性小鼠淋巴结和肺的T细胞克隆进行表征。
Clin Exp Immunol. 2000 Aug;121(2):275-82. doi: 10.1046/j.1365-2249.2000.01222.x.
5
Pseudomonas aeruginosa exoenzyme S induces transcriptional expression of proinflammatory cytokines and chemokines.铜绿假单胞菌外毒素S诱导促炎细胞因子和趋化因子的转录表达。
Infect Immun. 2000 Aug;68(8):4811-4. doi: 10.1128/IAI.68.8.4811-4814.2000.
6
Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats.用灭活铜绿假单胞菌进行黏膜和全身免疫可预防大鼠急性呼吸道感染。
Infect Immun. 1994 Apr;62(4):1427-36. doi: 10.1128/iai.62.4.1427-1436.1994.
7
Intact splenic function in cystic fibrosis.囊性纤维化患者的脾脏功能完整。
J Natl Med Assoc. 1994 Apr;86(4):270-2.
8
A role for CD4+ T cells from orally immunized rats in enhanced clearance of Pseudomonas aeruginosa from the lung.口服免疫大鼠的CD4 + T细胞在增强从肺部清除铜绿假单胞菌中的作用。
Immunology. 1994 Nov;83(3):362-9.
9
In vitro and in vivo T cell responses in mice during bronchopulmonary infection with mucoid Pseudomonas aeruginosa.黏液型铜绿假单胞菌支气管肺部感染期间小鼠的体外和体内T细胞应答
Clin Exp Immunol. 1995 Jan;99(1):98-105. doi: 10.1111/j.1365-2249.1995.tb03478.x.
10
Pseudomonas aeruginosa exoenzyme S induces proliferation of human T lymphocytes.铜绿假单胞菌外毒素S可诱导人T淋巴细胞增殖。
Infect Immun. 1995 May;63(5):1800-5. doi: 10.1128/iai.63.5.1800-1805.1995.

本文引用的文献

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A 5 YEAR CLINICAL EVALUATION OF A THERAPEUTIC PROGRAM FOR PATIENTS WITH CYSTIC FIBROSIS.一项针对囊性纤维化患者治疗方案的5年临床评估
J Pediatr. 1964 Nov;65:677-93. doi: 10.1016/s0022-3476(64)80152-9.
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Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period.对105例囊性纤维化患者进行的长期研究；研究历时5至14年。
AMA J Dis Child. 1958 Jul;96(1):6-15. doi: 10.1001/archpedi.1958.02060060008002.
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Serum immunoglobulin levels in cystic fibrosis.囊性纤维化患者的血清免疫球蛋白水平
Am J Dis Child. 1966 Apr;111(4):408-11. doi: 10.1001/archpedi.1966.02090070106015.
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Activation of normal rabbit macrophage monolayers by supernatants of antigen-stimulated lymphocytes.抗原刺激淋巴细胞的上清液对正常兔巨噬细胞单层的激活作用。
J Immunol. 1970 Nov;105(5):1138-45.
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Lymphocyte-mediated modification of blood-derived macrophage function in vitro; inhibition of growth of intracellular mycobacteria with lymphokines.淋巴细胞介导的体外血液源性巨噬细胞功能的改变；淋巴因子对细胞内分枝杆菌生长的抑制作用。
Clin Exp Immunol. 1971 Apr;8(4):625-37.
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In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes.经特异性致敏的淋巴细胞在体外诱导巨噬细胞产生非特异性抵抗力。
Infect Immun. 1971 Oct;4(4):337-43. doi: 10.1128/iai.4.4.337-343.1971.
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Production of antibody against Pseudomonas aeruginosa and its serological typing.抗铜绿假单胞菌抗体的产生及其血清学分型。
Jpn J Exp Med. 1971 Feb;41(1):89-94.
8
The influence of immunologically committed lymphoid cells on macrophage activity in vivo.免疫致敏淋巴细胞对体内巨噬细胞活性的影响。
J Exp Med. 1969 May 1;129(5):973-92. doi: 10.1084/jem.129.5.973.
9
The enhancement of macrophage bacteriostasis by products of activated lymphocytes.活化淋巴细胞产物对巨噬细胞抑菌作用的增强。
J Exp Med. 1973 Oct 1;138(4):952-64. doi: 10.1084/jem.138.4.952.
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Bacterial precipitins in serum of patients with cystic fibrosis.囊性纤维化患者血清中的细菌沉淀素。
Lancet. 1968 Feb 10;1(7537):270-2. doi: 10.1016/s0140-6736(68)90121-9.

对细菌的细胞免疫：囊性纤维化患者体外淋巴细胞对铜绿假单胞菌反应的受损情况。

Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.

作者信息

Sorensen R U, Stern R C, Polmar S H

出版信息

Infect Immun. 1977 Dec;18(3):735-40. doi: 10.1128/iai.18.3.735-740.1977.

DOI:10.1128/iai.18.3.735-740.1977
PMID:412789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421296/
Abstract

Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A and to Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa were evaluated in patients with cystic fibrosis and in normal individuals. Lymphocyte proliferation in vitro was stimulated by gentamicin-killed whole bacteria, and the proliferative response was measured by [3H]thymidine incorporation. The in vitro lymphocyte responses to antibiotic-killed bacterial reached maximum thymidine incorporation after 5 days in culture and followed a unimodal dose-response curve for each of the bacteria studied. A significant specific incapacity to respond to P. aeruginosa was detected in cystic fibrosis patients with advanced clinical disease.

摘要

在囊性纤维化患者和正常个体中评估了淋巴细胞对有丝分裂原植物血凝素和刀豆球蛋白A以及对化脓性链球菌、金黄色葡萄球菌、流感嗜血杆菌和铜绿假单胞菌的反应。用庆大霉素杀死的全菌刺激体外淋巴细胞增殖，并通过[3H]胸苷掺入来测量增殖反应。体外淋巴细胞对经抗生素杀死细菌的反应在培养5天后达到最大胸苷掺入量，并且对于所研究的每种细菌均呈现单峰剂量反应曲线。在患有晚期临床疾病的囊性纤维化患者中检测到对铜绿假单胞菌反应的显著特异性无能。