Savchenko Iu N, Ereniev S I, Genne R I, Semchenko V V
Zh Nevrol Psikhiatr Im S S Korsakova. 1993;93(1):3-7.
Experiments were made on rats of two lines during 120-140 days. A study was made of the effect of transplanting the embryonal hippocamp tissue and the septum (E 18) on the phenotypically (mechanical destruction in Wistar rats of the areas CA1 and CA4 of the fields of the hippocamp and dentate gyrus) and genotypically (Krushinskiĭ-Molodkina rats, all responding to graded acoustic stimulations (86 dB) by audiogenic convulsive fits) determined high convulsive activity of the brain. It has been shown that from days 4-6, in 19 out of 23 Wistar rats, the transplantation was followed by a steady increase of the threshold of convulsive activity. As to the threshold of convulsive activity in K-M rats, it was affected by the transplantation to a slightly less measure. Out of 17 K-M rats, 9 stopped reacting to acoustic stimulations by audiogenic convulsive fits from days 39-44. In 5 more animals, convulsive fits failed to occur after every acoustic stimulation, the duration of the clonic and tonic phases of convulsive fit and the duration of the post-paroxysmal motor excitation declined.
在120至140天期间，对两个品系的大鼠进行了实验。研究了移植胚胎海马组织和隔膜（胚胎第18天）对表型（对Wistar大鼠海马和齿状回区域CA1和CA4进行机械破坏）和基因型（克鲁申斯基-莫洛迪纳大鼠，所有大鼠对分级听觉刺激（86分贝）都会产生听源性惊厥发作）确定的大脑高惊厥活性的影响。结果表明，从第4至6天起，23只Wistar大鼠中有19只在移植后惊厥活性阈值稳步升高。至于K-M大鼠的惊厥活性阈值，移植对其影响程度稍小。在17只K-M大鼠中，9只从第39至44天起不再对听觉刺激产生听源性惊厥发作。另外5只动物在每次听觉刺激后不再出现惊厥发作，惊厥发作的阵挛期和强直期持续时间以及发作后运动兴奋持续时间均缩短。
