Kühne J H, Bartl R, Frisch B, Hammer C, Jansson V, Zimmer M
Department of Orthopedics, Ludwig-Maximilians University Munich, Germany.
Acta Orthop Scand. 1994 Jun;65(3):246-52. doi: 10.3109/17453679408995448.
We analyzed osseous reactions in the rabbit femoral condyle to coralline hydroxyapatite bone substitutes of various pore sizes by radiology and histology. The results were compared to bone repair of empty cavities and to integration of allografts. Spontaneous bone repair of the empty cavities took approximately 12 weeks, while integration of the cryopreserved allografts occurred after 9 weeks. However, no signs of new bone formation were found with the 200 microns pore size hydroxyapatite. In contrast, there was substantial production of bone within the 500 microns pore size implants at 12 and 26 weeks. Our results indicate that the pore size of the coralline hydroxyapatite influenced the development of bone in the implants in the cancellous bone bed of the rabbit femoral condyle. The results also show that spontaneous bone repair should be taken into consideration when the integration of implants is evaluated.
我们通过放射学和组织学分析了兔股骨髁对不同孔径珊瑚羟基磷灰石骨替代物的骨反应。将结果与空洞的骨修复以及同种异体移植物的整合进行了比较。空洞的自发骨修复大约需要12周，而冷冻保存的同种异体移植物在9周后发生整合。然而，在孔径为200微米的羟基磷灰石中未发现新骨形成的迹象。相比之下，在12周和26周时，孔径为500微米的植入物内有大量骨生成。我们的结果表明，珊瑚羟基磷灰石的孔径影响了兔股骨髁松质骨床植入物中骨的发育。结果还表明，在评估植入物的整合时应考虑自发骨修复。
