• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Antibody-mediated clearance of viruses from the mammalian central nervous system.抗体介导的病毒从哺乳动物中枢神经系统的清除。
Trends Microbiol. 1993 May;1(2):63-6. doi: 10.1016/0966-842x(93)90035-p.
2
Germ Line IgM Is Sufficient, but Not Required, for Antibody-Mediated Alphavirus Clearance from the Central Nervous System.生殖系IgM对于抗体介导的从中枢神经系统清除甲病毒是足够的，但并非必需的。
J Virol. 2018 Mar 14;92(7). doi: 10.1128/JVI.02081-17. Print 2018 Apr 1.
3
The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system.入侵 B 细胞产生的抗体对于清除中枢神经系统中的狂犬病毒是必需的。
PLoS Negl Trop Dis. 2009 Oct 6;3(10):e535. doi: 10.1371/journal.pntd.0000535.
4
Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice.静脉注射病毒中和抗体以清除小鼠大脑中已建立的狂犬病病毒感染并预防狂犬病的发生，需要增强血脑屏障的通透性。
Antiviral Res. 2014 Oct;110:132-41. doi: 10.1016/j.antiviral.2014.07.013. Epub 2014 Aug 7.
5
Viral antibody in the cerebrospinal fluid of patients with acute central nervous system infections.急性中枢神经系统感染患者脑脊液中的病毒抗体。
J Clin Microbiol. 1976 Apr;3(4):397-401. doi: 10.1128/jcm.3.4.397-401.1976.
6
Control of Sindbis virus infection by antibody in interferon-deficient mice.干扰素缺陷小鼠中抗体对辛德毕斯病毒感染的控制
J Virol. 2000 Apr;74(8):3905-8. doi: 10.1128/jvi.74.8.3905-3908.2000.
7
Immune evasion by rabies viruses through the maintenance of blood-brain barrier integrity.狂犬病病毒通过维持血脑屏障完整性实现免疫逃逸。
J Neurovirol. 2008 Oct;14(5):401-11. doi: 10.1080/13550280802235924. Epub 2008 Nov 18.
8
Interleukin-10 Modulation of Virus Clearance and Disease in Mice with Alphaviral Encephalomyelitis.α病毒脑脊髓炎小鼠中白细胞介素-10对病毒清除及疾病的调节作用
J Virol. 2018 Feb 26;92(6). doi: 10.1128/JVI.01517-17. Print 2018 Mar 15.
9
Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons.病毒性脑炎的恢复：免疫介导的神经元非细胞溶解病毒清除。
Immunol Res. 2010 Jul;47(1-3):123-33. doi: 10.1007/s12026-009-8143-4.
10
Vaccines against viruses associated with diseases in human central nervous system.针对与人类中枢神经系统疾病相关病毒的疫苗。
Adv Biotechnol Processes. 1990;14:243-77.

引用本文的文献

1
Green-to-red spectral labeling: A novel polysynaptic retrograde tracing strategy in the marker footprint mouse model.绿到红光谱标记：标记足迹小鼠模型中的一种新型多突触逆行追踪策略。
Animal Model Exp Med. 2025 Apr 25. doi: 10.1002/ame2.70025.
2
Antiviral mechanisms of two broad-spectrum monoclonal antibodies for rabies prophylaxis and therapy.两种广谱抗狂犬病单克隆抗体的抗病毒机制用于狂犬病的预防和治疗。
Front Immunol. 2023 Aug 10;14:1186063. doi: 10.3389/fimmu.2023.1186063. eCollection 2023.
3
Development and Evaluation of an Enzyme-Linked Immunosorbent Assay Targeting Rabies-Specific IgM and IgG in Human Sera.开发和评估一种酶联免疫吸附试验，用于检测人血清中的狂犬病特异性 IgM 和 IgG。
Viruses. 2023 Mar 29;15(4):874. doi: 10.3390/v15040874.
4
Investigating the Efficacy of a Canine Rabies Vaccine Following Storage Outside of the Cold-Chain in a Passive Cooling Device.研究犬用狂犬病疫苗在被动冷却装置中冷链外储存后的效力。
Front Vet Sci. 2021 Sep 29;8:728271. doi: 10.3389/fvets.2021.728271. eCollection 2021.
5
Challenges of Rabies Serology: Defining Context of Interpretation.狂犬病血清学检测面临的挑战：解读的背景定义。
Viruses. 2021 Jul 31;13(8):1516. doi: 10.3390/v13081516.
6
Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis.干扰素γ对疾病表现及针对甲病毒脑脊髓炎的局部抗体反应的调节作用
J Gen Virol. 2016 Nov;97(11):2908-2925. doi: 10.1099/jgv.0.000613. Epub 2016 Sep 22.
7
Intrathecal humoral immunity to encephalitic RNA viruses.鞘内体液免疫反应对脑炎 RNA 病毒的影响
Viruses. 2013 Feb 15;5(2):732-52. doi: 10.3390/v5020732.
8
Rabies-specific antibodies: measuring surrogates of protection against a fatal disease.狂犬病特异性抗体：衡量针对致命疾病的保护替代指标。
PLoS Negl Trop Dis. 2010 Mar 9;4(3):e595. doi: 10.1371/journal.pntd.0000595.
9
Insights into the role of immune activation in HIV neuropathogenesis.深入了解免疫激活在HIV神经发病机制中的作用。
J Neurovirol. 2002 Apr;8(2):69-75. doi: 10.1080/13550280290049525.
10
Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration.受损神经系统中的免疫监视：T淋巴细胞侵入切断轴突的小鼠面神经运动核并聚集在神经元变性部位周围。
J Neurosci. 1998 Aug 1;18(15):5804-16. doi: 10.1523/JNEUROSCI.18-15-05804.1998.

本文引用的文献

1
Breakdown of the blood--cerebrospinal fluid barrier to immunoglobulin in mice injected intracerebrally with a neurotropic influenza A virus. Post-exposure treatment with monoclonal antibody promotes recovery.用嗜神经性甲型流感病毒脑内注射小鼠后，血脑屏障对免疫球蛋白的破坏。暴露后用单克隆抗体治疗可促进恢复。
J Neuroimmunol. 1981 Sep;1(3):227-37. doi: 10.1016/0165-5728(81)90027-8.
2
Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis.免疫T细胞在小鼠淋巴细胞性脉络丛脑膜炎中可起到保护作用或引发致命的神经疾病。
Cell Immunol. 1985 Feb;90(2):401-7. doi: 10.1016/0008-8749(85)90204-7.
3
Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.小鼠抗狂犬病单克隆抗体在狂犬病暴露后治疗中的应用。
J Clin Invest. 1989 Sep;84(3):971-5. doi: 10.1172/JCI114260.
4
Coupling of viral membrane proteins to phosphatidylinositide signalling system.病毒膜蛋白与磷脂酰肌醇信号系统的偶联。
FEBS Lett. 1989 Apr 24;247(2):185-8. doi: 10.1016/0014-5793(89)81330-4.
5
Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry.通过免疫细胞化学定义的血脑屏障的分子解剖学。
Int Rev Cytol. 1991;127:57-109. doi: 10.1016/s0074-7696(08)60692-0.
6
The tachykinin neuroimmune connection in inflammatory pain.炎症性疼痛中的速激肽神经免疫联系
Ann N Y Acad Sci. 1991;632:283-95. doi: 10.1111/j.1749-6632.1991.tb33116.x.
7
Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection.抗病毒抗体可减轻急性淋巴细胞性脉络丛脑膜炎病毒感染后T细胞介导的免疫病理反应。
J Virol. 1991 Jun;65(6):3001-6. doi: 10.1128/JVI.65.6.3001-3006.1991.
8
A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig.豚鼠血脑屏障上免疫球蛋白G转运的饱和机制。
Exp Neurol. 1990 Mar;107(3):263-70. doi: 10.1016/0014-4886(90)90144-h.
9
Antibody-mediated clearance of alphavirus infection from neurons.抗体介导的从神经元中清除甲病毒感染。
Science. 1991 Nov 8;254(5033):856-60. doi: 10.1126/science.1658936.
10
Antibody-dependent transcriptional regulation of measles virus in persistently infected neural cells.持续性感染神经细胞中麻疹病毒的抗体依赖性转录调控
J Virol. 1992 Sep;66(9):5534-41. doi: 10.1128/JVI.66.9.5534-5541.1992.

抗体介导的病毒从哺乳动物中枢神经系统的清除。

Antibody-mediated clearance of viruses from the mammalian central nervous system.

作者信息

Dietzschold B

机构信息

Center of Neurovirology, Thomas Jefferson University, Philadelphia, PA 19107.

出版信息

Trends Microbiol. 1993 May;1(2):63-6. doi: 10.1016/0966-842x(93)90035-p.

DOI:10.1016/0966-842x(93)90035-p
PMID:8044464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7133251/
Abstract

The novel role of antibody in clearing virus from the central nervous system without the help of other immune effectors is an important phenomenon that has only recently been documented. Possible routes for antibodies across the blood-brain barrier and how they work in the CNS are discussed here.

摘要

抗体在没有其他免疫效应器帮助的情况下从中枢神经系统清除病毒的新作用是一种重要现象，直到最近才被记录下来。本文讨论了抗体穿过血脑屏障的可能途径以及它们在中枢神经系统中的作用方式。