Nielsen S L, Wilson C B
J Neuropathol Exp Neurol. 1975 Mar;34(2):148-58. doi: 10.1097/00005072-197503000-00003.
The commonest pineal gland tumor, the germinoma, is more apparently related to germ cells than to pineal cells. Although ultrastructural studies of this tumor have confirmed this similarity, comparable characterization of a pineocytoma has not been reported, due to its rarity. Here we define the electron microscopic features of a rapidly growing human pineocytoma and compare the tumor cells in the present study with normal mammalian pinealocytes, as well as with cells described in the literature of pineal body pathology. Two cell types populate the tumor: one resembles the neuron, while the second, less frequently encountered, is often indistinguishable from the fibrous astrocyte. Synaptic complexes and dense-cored vesicles were not conspicuous fine-structural elements. Whereas emphatic morphological differences exist between the germinoma and pineocytoma, the similarities in ultrastructure between the pineocytoma cells and adult mammalian pinealocytes are even more striking.
最常见的松果体肿瘤——生殖细胞瘤，与生殖细胞的关系比与松果体细胞的关系更为明显。尽管对该肿瘤的超微结构研究已证实了这种相似性，但由于松果体细胞瘤罕见，尚未见对其进行类似特征描述的报道。在此，我们明确了一例快速生长的人类松果体细胞瘤的电镜特征，并将本研究中的肿瘤细胞与正常哺乳动物松果体细胞以及松果体病理学文献中描述的细胞进行比较。肿瘤中有两种细胞类型：一种类似于神经元，而另一种较少见，常与纤维性星形胶质细胞难以区分。突触复合体和致密核心小泡并非明显的精细结构成分。虽然生殖细胞瘤和松果体细胞瘤在形态上存在显著差异，但松果体细胞瘤细胞与成年哺乳动物松果体细胞在超微结构上的相似性更为显著。
