Moore J E, Maier S E, Ku D N, Boesiger P
School of Mechanical Engineering, Georgia Institute of Technology, Atlanta 30332-0405.
J Appl Physiol (1985). 1994 Apr;76(4):1520-7. doi: 10.1152/jappl.1994.76.4.1520.
In vivo measurements of blood velocity profiles are difficult to obtain and interpret, since the parameters that govern the normally highly complex flow situation may not be fully quantified or understood at the time of measurement. In vitro flow models have been used often to better understand vascular hemodynamics. The assumptions made in the design of these models limit the applicability of the results. In this study, in vitro flow measurements made in a carefully designed model of the abdominal aorta were compared with in vivo measurements obtained with magnetic resonance imaging. In the suprarenal aorta, the velocity profiles were mostly forward and axisymmetric in both the in vitro and in vivo cases. In the infrarenal aorta, there was extensive flow reversal noted near the posterior wall in both cases. In the aortic bifurcation, two peaks of flow reversal were noted near the lateral posterior walls, and M-shaped velocity profiles were observed in late diastole. The in vitro and in vivo measurements exhibited good qualitative agreement. The in vitro model was accurate in modeling the in vivo hemodynamics of the abdominal aorta. The complex phenomena observed in vivo were explained on the basis of knowledge gained from the in vitro study.
体内血流速度剖面的测量难以获取和解释，因为在测量时，控制通常高度复杂血流情况的参数可能无法完全量化或理解。体外血流模型经常被用于更好地理解血管血液动力学。这些模型设计中所做的假设限制了结果的适用性。在本研究中，将在精心设计的腹主动脉模型中进行的体外血流测量与通过磁共振成像获得的体内测量结果进行了比较。在肾上腹主动脉中，体外和体内情况下的速度剖面大多是向前且轴对称的。在肾下腹主动脉中，两种情况下在后壁附近均观察到广泛的血流逆转。在主动脉分叉处，在外侧后壁附近观察到两个血流逆转峰值，并且在舒张末期观察到M形速度剖面。体外和体内测量结果在定性上具有良好的一致性。体外模型在模拟腹主动脉的体内血液动力学方面是准确的。基于从体外研究中获得的知识，对体内观察到的复杂现象进行了解释。
