胸腔积液中蝶呤、可溶性白细胞介素-2受体及腺苷脱氨酶水平

Neopterin, soluble interleukin-2 receptor and adenosine deaminase levels in pleural effusions.

作者信息

Chiang C S, Chiang C D, Lin J W, Huang P L, Chu J J

机构信息

Division of Chest Medicine, Taichung, Veterans General Hospital, Taiwan, ROC.

出版信息

Respiration. 1994;61(3):150-4. doi: 10.1159/000196327.

DOI:10.1159/000196327

PMID:8047718

Abstract

We evaluated soluble interleukin-2 receptors (sIL-2R), neopterin and adenosine deaminase (ADA) in pleural effusions from 93 patients with tuberculosis, malignancies, uremia, pneumonia and other kinds of pleurisy. There were significantly elevated ADA (102.7 +/- 47 U/l) and sIL-2R (8,238 +/- 4,117 U/ml) values in tuberculous (TB) pleural fluids as compared with other non-TB pleural fluids (p < 0.005). The neopterin levels in pleural fluid were significantly lower in the cancer group (17.3 +/- 7.8 nmol/l; p < 0.005) and most strikingly elevated (309.4 +/- 112.2 nmol/l; p < 0.0001) in patients with uremic pleural effusions. Using cut-off values of 60 U/l in ADA and 5,000 U/l in sIL-2R, 92.0 and 86.9% of pleural effusions were TB in origin. Eighty-four percent of patients with malignant pleural effusions had neopterin levels less than 25 nmol/l.

摘要

我们对93例患有结核病、恶性肿瘤、尿毒症、肺炎及其他类型胸膜炎患者的胸腔积液中的可溶性白细胞介素-2受体（sIL-2R）、新蝶呤和腺苷脱氨酶（ADA）进行了评估。与其他非结核性胸腔积液相比，结核性（TB）胸腔积液中的ADA（102.7±47 U/l）和sIL-2R（8238±4117 U/ml）值显著升高（p<0.005）。癌症组胸腔积液中的新蝶呤水平显著降低（17.3±7.8 nmol/l；p<0.005），而尿毒症性胸腔积液患者的新蝶呤水平则显著升高（309.4±112.2 nmol/l；p<0.0001）。以ADA 60 U/l和sIL-2R 5000 U/l为临界值，92.0%和86.9%的胸腔积液起源于结核。84%的恶性胸腔积液患者新蝶呤水平低于25 nmol/l。