Cooksley W G, Powell L W, Mistilis S P, Mackay I R, Barker L F
Am J Dig Dis. 1975 Feb;20(2):110-4. doi: 10.1007/BF01072335.
In a multicenter cooperative study, sera from 85 patients with active chronic hepatitis (ACH) were examined for the presence of hepatitis B (Australia) antigen (HBAg) by radioimmunoassay (RIA) and antibody to HBAg (anti-HBAg) by RIA and passive hemagglutination (PHA), the most sensitive currently available techniques. In addition, sera from 83 patients with other liver diseases 98 other hospital patients, and 67 healthy controls were tested. HBAg was detected in 3 of the 85 patients (four percent) with ACH. In a further 3 patients (four percent) anti-HBAg was detected. Thus, 6 patients with ACH (seven percent) had evidence of present or prior infection with the hepatitis B virus (HBV). HBAg was also detected in 7 of the patients with other liver diseases, 2 of the other hospital patients, and none of the healthy controls. Anti-HBAg was detected in 17 of the non-ACH subjects. These results indicate that neither persistent nor prior self-limited infection with HBV is a major factor in the pathogenesis of ACH in Australia.
在一项多中心合作研究中，采用放射免疫测定法（RIA）检测了85例活动性慢性肝炎（ACH）患者血清中乙型肝炎（澳大利亚）抗原（HBAg）的存在情况，并采用RIA和被动血凝试验（PHA）检测了其抗HBAg抗体，这两种方法是目前最敏感的技术。此外，还检测了83例其他肝病患者、98例其他医院患者以及67例健康对照者的血清。在85例ACH患者中有3例（4%）检测到HBAg。另有3例（4%）检测到抗HBAg。因此，6例ACH患者（7%）有目前或既往感染乙型肝炎病毒（HBV）的证据。在其他肝病患者中有7例检测到HBAg，其他医院患者中有2例检测到HBAg，健康对照者中未检测到HBAg。在非ACH受试者中有17例检测到抗HBAg。这些结果表明，在澳大利亚，持续性或既往自限性HBV感染均不是ACH发病机制中的主要因素。
