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慢性肝病与乙肝抗原：一项前瞻性研究。

Chronic liver disease and hepatitis-B antigen: a prospective study.

作者信息

Van Waes L, Segers J, Van Egmond J, Van Nimmen L, Barbier F, Wieme R, Demeulenaere L

出版信息

Br Med J. 1974 Aug 17;3(5928):444-6. doi: 10.1136/bmj.3.5928.444.

DOI:10.1136/bmj.3.5928.444
PMID:4212993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1611455/
Abstract

A long-term follow-up of 45 patients with chronic hepatitis and 41 with cirrhosis is reported. Hepatitis-B antigen (HBAg) was present in 19 (42%) of the chronic hepatitis patients and in 20 (49%) of those with cirrhosis. The clinical course and biochemical and histological findings in the HBAg-positive and the HBAg-negative cases were similar, suggesting that HBAg-positive chronic liver disease is not a distinct clinical entity. The presence of antigen and autoantibodies was not found to be mutually exclusive. In HBAg-positive cases antigen tended to persist for months and years. When no irreversible lesions exist disappearance of the antigen may be a sign that the liver disease will resolve.

摘要

报告了对45例慢性肝炎患者和41例肝硬化患者的长期随访情况。19例（42%）慢性肝炎患者和20例（49%）肝硬化患者存在乙型肝炎抗原（HBAg）。HBAg阳性和HBAg阴性病例的临床病程以及生化和组织学检查结果相似，这表明HBAg阳性慢性肝病并非一种独特的临床实体。未发现抗原和自身抗体的存在相互排斥。在HBAg阳性病例中，抗原往往会持续数月甚至数年。当不存在不可逆病变时，抗原消失可能是肝病将痊愈的迹象。

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Chronic liver disease and hepatitis-B antigen: a prospective study.慢性肝病与乙肝抗原：一项前瞻性研究。
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本文引用的文献

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Au-SH-antigen in liver disease.肝病中的金-硫抗原
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Australia antigen in acute and chronic liver disease.急慢性肝病中的澳大利亚抗原
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Treatment of chronic active hepatitis.
Lancet. 1973 May 19;1(7812):1124. doi: 10.1016/s0140-6736(73)90438-8.

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