Takayama S, Iwasaki Y, Yamanouchi H, Sugai K, Takashima S, Iwasaki A
Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Kodaira, Japan.
Brain Dev. 1994 Mar-Apr;16(2):132-5. doi: 10.1016/0387-7604(94)90049-3.
A 12-year-old girl with fulminant subacute sclerosing panencephalitis (SSPE) without myoclonic jerk and periodic EEG complexes is reported. She presented with blurred vision, fell into a coma after 2 weeks and died within 4 months. Magnetic resonance image (MRI) disclosed high intensity lesions in the lateral geniculate bodies, when the patient initially complained of blurred vision. Reviewing the cases of fulminant SSPE in the literature, more than half of the patients showed blurred vision or visual agnosia as an initial symptom. Most of those patients were female and rapidly deteriorated to a comatose state within 2 weeks. Based on the MRI study of the present patient, we speculate that the initial visual impairment in such patients can be attributed to the involvement of the lateral geniculate body.
报告了一名12岁患有暴发性亚急性硬化性全脑炎（SSPE）的女孩，她没有肌阵挛性抽搐和周期性脑电图复合波。她最初出现视力模糊，2周后陷入昏迷，并在4个月内死亡。当患者最初主诉视力模糊时，磁共振成像（MRI）显示外侧膝状体有高强度病变。回顾文献中暴发性SSPE的病例，超过一半的患者以视力模糊或视觉失认作为初始症状。这些患者大多数为女性，并在2周内迅速恶化为昏迷状态。基于本患者的MRI研究，我们推测此类患者最初的视觉障碍可归因于外侧膝状体受累。
