Decauchy F, Beauvais L, Meunier L, Meynadier J
Service de dermatologie allergologie et photobiologie, hôpital Saint-Charles, Montpellier.
Rev Prat. 1993 Nov 15;43(18):2344-8.
Rosacea is a frequent disease which occurs mostly in women with dry skin and much more rarely in men with greasy skin. In women, rosacea is heralded, around the age of 20 years, by intermittent facial erythema, and this is followed by the gradual development of permanent erythema (erythrosis) with telangiectasia (couperose) and later on, around the age of 40, very unsightly papulo-pustules (papular rosacea, improperly called acne rosacea). In men, these successive stages are less frequent, but progressive dilatation of the nose due to sebaceous gland overgrowth may occur (rhinophyma). Rosacea is caused by vascular abnormalities not completely determined, and also, at the papulo-pustural stage, by a small parasite called Demodex folliculorum. Treatment rests on hygienic and dietary rules and vasoconstrictor drugs at the erythema stage, then on fine electrocoagulation or pulsed dye laser to suppress couperose and on the prescription of long-term low-dose tetracycline, sometimes preceded by a 2-month course of metronidazole to remove the papulo-pustules. Rhinophyma is treated by surgery. The results obtained are remarkable, at least on couperose, papulo-pustules and rhinophyma.
酒渣鼻是一种常见疾病,多见于干性皮肤的女性,油性皮肤的男性则更为罕见。在女性中,酒渣鼻通常在20岁左右以间歇性面部红斑为先兆,随后逐渐发展为伴有毛细血管扩张(玫瑰痤疮)的永久性红斑(红斑症),之后在40岁左右,会出现非常难看的丘疹脓疱(丘疹性酒渣鼻,误称为痤疮样酒渣鼻)。在男性中,这些连续阶段较少见,但由于皮脂腺过度增生可能会出现鼻子逐渐肿大(肥大性酒渣鼻)。酒渣鼻是由尚未完全明确的血管异常引起的,在丘疹脓疱阶段,还由一种名为毛囊蠕形螨的小寄生虫引起。治疗方法包括在红斑阶段遵循卫生和饮食规则并使用血管收缩药物,然后采用精细电凝或脉冲染料激光来消除毛细血管扩张,以及长期低剂量四环素的处方,有时在使用甲硝唑进行为期2个月的疗程以消除丘疹脓疱之后。肥大性酒渣鼻通过手术治疗。所取得的效果显著,至少在毛细血管扩张、丘疹脓疱和肥大性酒渣鼻方面是如此。