Champion G L, Richter J E
Division of Gastroenterology, University of Alabama at Birmingham.
Gastroenterologist. 1993 Mar;1(1):18-33.
Over the past 2 decades, we have learned a great deal about the atypical presentations of gastroesophageal reflux disease (GERD). Both distal and proximal reflux of gastric contents are associated with a variety of extraesophageal manifestations, including angina-like chest pain, pulmonary, or otolaryngological problems. Whereas the esophagus is usually the first target of injury in GERD, any contiguous structure can be affected either by direct contact of gastric contents or via a reflex-mediated mechanism. The expanding use of ambulatory esophageal pH studies, especially with dual pH probe monitoring, should provide a clearer understanding of the pathophysiology of these disorders and allow more successful treatment in the future.
在过去的20年里，我们对胃食管反流病（GERD）的非典型表现有了很多了解。胃内容物的远端和近端反流都与多种食管外表现有关，包括心绞痛样胸痛、肺部或耳鼻喉科问题。虽然食管通常是GERD中第一个受损的靶器官，但任何相邻结构都可能因胃内容物的直接接触或通过反射介导机制而受到影响。动态食管pH监测的广泛应用，尤其是双pH探头监测，应该能让我们更清楚地了解这些疾病的病理生理学，并在未来实现更成功的治疗。
