老年小鼠大脑中线粒体氧化磷酸化功能受损。
Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice.
作者信息
Ferrándiz M L, Martínez M, De Juan E, Díez A, Bustos G, Miquel J
机构信息
Instituto de Neurociencias, Facultad de Medicina, Universidad de Alicante, Spain.
出版信息
Brain Res. 1994 May 2;644(2):335-8. doi: 10.1016/0006-8993(94)91699-3.
To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.
为阐明线粒体氧化磷酸化在神经元衰老中的作用，我们研究了年轻、成年和老年小鼠大脑中呼吸复合体的活性。在突触线粒体中，我们发现老年小鼠与成年小鼠相比，复合体IV（降低29%，P < 0.001）和复合体V（降低21%，P < 0.01）的活性显著下降。非突触线粒体中，复合体I（降低15%，P < 0.01）、复合体II + III（降低34%，P < 0.01）和复合体IV（降低17%，P < 0.01）的活性也呈现衰老性下降。这些发现表明大脑衰老过程中线粒体氧化磷酸化功能存在障碍。
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