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本文引用的文献

1
A clinical trial on the efficacy of clemastine in the management of allergic pruritus in dogs.一项关于氯马斯汀治疗犬过敏性瘙痒疗效的临床试验。
Can Vet J. 1993 Jan;34(1):25-7.
2
Nonsteroidal anti-inflammatory agents in the management of canine allergic pruritus.非甾体抗炎药在犬过敏性瘙痒症治疗中的应用
J S Afr Vet Assoc. 1993 Mar;64(1):52-6.
3
Metabolic disposition of terfenadine in laboratory animals.特非那定在实验动物体内的代谢情况。
Arzneimittelforschung. 1982;32(9a):1173-8.
4
Absence of an effect of terfenadine on guinea pig brain histamine H1-receptors in vivo determined by receptor binding techniques.采用受体结合技术测定特非那定对豚鼠脑内组胺H1受体在体内无作用。
Arzneimittelforschung. 1982;32(9a):1167-70.
5
Treatment of chronic idiopathic urticaria with terfenadine.用特非那定治疗慢性特发性荨麻疹。
Clin Allergy. 1984 Mar;14(2):139-41. doi: 10.1111/j.1365-2222.1984.tb02644.x.
6
The effect of terfenadine on dermographic wealing.特非那定对皮肤划痕症风团的作用。
Br J Dermatol. 1984 Jan;110(1):73-9. doi: 10.1111/j.1365-2133.1984.tb07315.x.
7
Preclinical safety studies with terfenadine.特非那定的临床前安全性研究。
Arzneimittelforschung. 1982;32(9a):1179-84.
8
Double-blind comparison of terfenadine, chlorpheniramine, and placebo in the treatment of chronic idiopathic urticaria.特非那定、氯苯那敏和安慰剂治疗慢性特发性荨麻疹的双盲对照研究
J Allergy Clin Immunol. 1988 Mar;81(3):574-9.
9
Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans.阿司咪唑、特非那定和羟嗪对人体组胺诱发的风团和潮红抑制作用的比较。
J Allergy Clin Immunol. 1986 Feb;77(2):335-40. doi: 10.1016/s0091-6749(86)80114-2.
10
Antipruritic drugs.止痒药。
Vet Clin North Am Small Anim Pract. 1988 Sep;18(5):1093-9. doi: 10.1016/s0195-5616(88)50111-0.

特非那定作为异位性犬抗瘙痒剂的疗效不佳：一项双盲、安慰剂对照研究的结果。

Failure of terfenadine as an antipruritic agent in atopic dogs: results of a double-blinded, placebo-controlled study.

作者信息

Scott D W, Miller W H, Cayatte S M, Decker G A

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.

出版信息

Can Vet J. 1994 May;35(5):286-8.

PMID:8050074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1686655/
Abstract

Terfenadine (5 mg/kg body weight, q12h) and placebo (0.5 grain/dog q12h) were both administered orally as individual agents to 18 dogs with atopy in a double-blinded study. No dog improved. Hyperactivity, polyphagia, lethargy, anorexia, increased pruritus, or ocular discharge were seen in three dogs treated with terfenadine. Under the conditions of the study, terfenadine was not a useful antipruritic agent for the atopic dog.

摘要

在一项双盲研究中，将特非那定（5毫克/千克体重，每12小时一次）和安慰剂（0.5粒/只狗，每12小时一次）分别口服给予18只患有特应性皮炎的犬。没有一只犬病情好转。在三只接受特非那定治疗的犬中出现了多动、多食、嗜睡、厌食、瘙痒加剧或眼分泌物增多的情况。在该研究条件下，特非那定对患有特应性皮炎的犬不是一种有效的止痒剂。