Pollard M, Luckert P H
Lobund Laboratory, University of Notre Dame, IN 46556.
Cancer Lett. 1994 Jul 29;82(2):141-4. doi: 10.1016/0304-3835(94)90004-3.
Lobund-Wistar (L-W) rats are unique in their susceptibility to spontaneous and induced metastasizing adenocarcinomas in the prostate-seminal vesicle (P-SV) complex. Tumors were induced in 70-100% of rats by a combination of i.v. inoculated methylnitrosourea (MNU) followed by a series of subcutaneous slow-release implants of testosterone propionate (TP). Adenocarcinoma cells initiated by MNU in 3-month-old L-W rats were activated significantly by implants of the promoter, TP, after intervening periods of 3, 6 and 12 months following their exposures to MNU. The longer the time between MNU and TP, the shorter the subsequent latent period. Control rats inoculated with MNU (without TP) did not develop tumors during the observation period of 12 months, and their dormant tumor cells were activated by a single implant of TP, thereby eliciting P-SV tumors.
洛本德-威斯塔（L-W）大鼠在前列腺-精囊（P-SV）复合体中对自发性和诱发性转移性腺癌的易感性方面具有独特性。通过静脉注射甲基亚硝基脲（MNU），随后进行一系列皮下缓释丙酸睾酮（TP）植入的联合方法，可在70%-100%的大鼠中诱发肿瘤。在3月龄L-W大鼠中由MNU引发的腺癌细胞，在接触MNU后的3、6和12个月的间隔期后，通过启动子TP的植入而被显著激活。MNU与TP之间的时间间隔越长，随后的潜伏期就越短。接种MNU（无TP）的对照大鼠在12个月的观察期内未发生肿瘤，其休眠的肿瘤细胞通过单次植入TP而被激活，从而引发P-SV肿瘤。
