Pollard M, Luckert P H
Lobund Laboratory, University of Notre Dame, IN 46556, USA.
In Vivo. 1997 Jan-Feb;11(1):55-60.
Lobund-Wistar (L-W) rats develop adenocarcinomas spontaneously in the accessory sex glands (prostate-seminal vesicles) (P-SV) in the livers and in the lungs-all after long periods of latency. This report addresses (a) the multistage pattern of induced lung carcinomas in L-W rats and (b) the role(s) of two putative promotional agents (testosterone propionate (TP) and phenobarbital (PB) in the development of carcinomas in the lungs of L-W rats. Lung cancer is a rare slow-growing spontaneous neoplasm in L-W rats. Their incidence increased from 4.4% in avg 25.6 months (spontaneously) to 23.8% in avg 19 months following a single IV inoculation of methylnitrosourea (MNU), and further increased to 57% in avg 15 months by adding phenobarbital to the diet of MNU-inoculated rats. Three stages of lung tumorigenesis were manifested in L-W rats following treatments with MNU, or MNU + PB: hyperplasia, adenoma, and carcinoma.
洛本德-威斯塔（L-W）大鼠在副性腺（前列腺-精囊）、肝脏和肺部会自发发生腺癌，且均经过很长的潜伏期。本报告探讨了（a）L-W大鼠诱导性肺癌的多阶段模式，以及（b）两种假定的促癌剂（丙酸睾酮（TP）和苯巴比妥（PB））在L-W大鼠肺癌发生过程中的作用。肺癌在L-W大鼠中是一种罕见的生长缓慢的自发肿瘤。其发生率从平均25.6个月时的4.4%（自发）在单次静脉注射甲基亚硝基脲（MNU）后，升至平均19个月时的23.8%，通过在接种MNU的大鼠饮食中添加苯巴比妥，进一步升至平均15个月时的57%。在用MNU或MNU + PB处理后的L-W大鼠中，肺癌发生呈现三个阶段：增生、腺瘤和癌。
