Mandal P C, Gupta P P
Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana, India.
Mycopathologia. 1994 Apr;126(1):9-14. doi: 10.1007/BF01371167.
Intramammary inoculation of goats with Aspergillus fumigatus spores resulted in the development of mastitis with characteristic gross and microscopic lesions. The mastitis and the lesions were restricted to the infected udder halves only and there was no dissemination of infection to other tissues of the body. The experiment was continued for 45 days. Gross changes in the infected udder were observed up to the 45th day post-infection. The lesions, in general, included variable sized abscesses in the first 15 days followed by development of varying sized greyish-white nodules in the infected udders. Microscopic changes consisted of granulomatous reaction with well developed granulomas in the infected udders. Hyphae and spores of Aspergillus fumigatus could be demonstrated in sections of the infected udders up to 45 days after infection. Reisolation of the fungus consistently was achieved up to 45 days. It is concluded that intramammary inoculation of Aspergillus fumigatus spores in goats leads to chronic granulomatous mastitis.
给山羊乳腺内接种烟曲霉菌孢子会导致乳腺炎的发生，并伴有特征性的大体和微观病变。乳腺炎及病变仅局限于受感染的乳房半部，感染未扩散至身体的其他组织。实验持续了45天。在感染后第45天观察到受感染乳房的大体变化。一般来说，病变在最初15天包括大小不一的脓肿，随后在受感染的乳房中出现大小各异的灰白色结节。微观变化包括肉芽肿反应，在受感染的乳房中有发育良好的肉芽肿。在感染后45天内，在受感染乳房的切片中均可发现烟曲霉菌的菌丝和孢子。在45天内始终能够再次分离出该真菌。得出的结论是，给山羊乳腺内接种烟曲霉菌孢子会导致慢性肉芽肿性乳腺炎。
