Cappell M S
Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick.
Am J Gastroenterol. 1994 Aug;89(8):1241-5.
The anticardiolipin antibody syndrome has been previously associated with seven cases of gastrointestinal ischemia involving the duodenum, jejunoileum, or colon. In prior cases patients presented with gastrointestinal bleeding, abdominal pain, or an acute abdomen without gastrointestinal perforation. A patient with prior pulmonary emboli, right leg thrombophlebitis, and right popliteal artery thrombosis associated with anticardiolipin antibodies developed fatal esophageal ischemia. Postmortem examination revealed esophageal necrosis and perforation due to esophageal vascular thrombosis, as well as ischemic colitis and numerous other thromboembolic phenomena. This case report extends the gastrointestinal manifestations of the anticardiolipin antibody syndrome by describing esophageal involvement and by reporting the first case of alimentary tract perforation.
抗心磷脂抗体综合征此前已与7例涉及十二指肠、空肠回肠或结肠的胃肠道缺血病例相关。在之前的病例中，患者表现为胃肠道出血、腹痛或无胃肠道穿孔的急腹症。一名患有先前肺栓塞、右下肢血栓性静脉炎和与抗心磷脂抗体相关的右腘动脉血栓形成的患者发生了致命的食管缺血。尸检显示，食管血管血栓形成导致食管坏死和穿孔，以及缺血性结肠炎和许多其他血栓栓塞现象。本病例报告通过描述食管受累情况并报告首例消化道穿孔病例，扩展了抗心磷脂抗体综合征的胃肠道表现。
