Murphy C, Nordin S, de Wijk R A, Cain W S, Polich J
Department of Psychology, College of Sciences, San Diego State University, CA 92182.
Chem Senses. 1994 Feb;19(1):47-56. doi: 10.1093/chemse/19.1.47.
Olfactory-evoked potentials (OEPs) were recorded monopolarly at the Fz, Cz and Pz electrode sites in young adults and elderly subjects with an amyl acetate stimulus presented olfactometrically. Psychophysical odor thresholds for amyl acetate were determined using a two-alternative, forced-choice detection procedure. These demonstrated a decreased odor detection sensitivity in the elderly relative to tye young subjects. In accordance with the threshold findings, elderly subjects produced significantly smaller N1 and P2 amplitudes, and a trend towards longer latencies than younger subjects. Moreover, odor threshold was found to correlate with amplitude magnitude. The OEP findings, which are discussed in the context of previous OEP studies, offer promise as an objective, non-invasive measure of sensory function in both clinical and non-clinical settings.
在年轻成年人和老年受试者中，通过嗅觉测量法呈现醋酸戊酯刺激，在Fz、Cz和Pz电极部位单极记录嗅觉诱发电位（OEP）。使用二项选择、强迫选择检测程序确定醋酸戊酯的心理物理气味阈值。结果表明，与年轻受试者相比，老年人的气味检测敏感性降低。与阈值结果一致，老年受试者产生的N1和P2波幅明显较小，并且与年轻受试者相比有潜伏期延长的趋势。此外，发现气味阈值与波幅大小相关。在之前OEP研究的背景下讨论的OEP结果，有望成为临床和非临床环境中感觉功能的一种客观、非侵入性测量方法。
