使用紧凑型吸入装置和定量吸入器，对患有慢性阻塞性肺病的马匹快速有效地施用β2-激动剂。
The rapid and effective administration of a beta 2-agonist to horses with heaves using a compact inhalation device and metered-dose inhalers.
作者信息
Tesarowski D B, Viel L, McDonell W N, Newhouse M T
机构信息
Firestone Equine Respiratory Research Laboratory, Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
出版信息
Can Vet J. 1994 Mar;35(3):170-3.
The purpose of the study was to administer therapeutic aerosol generated by metered-dose inhalers to horses exhibiting clinical signs of heaves using a compact inhalation device developed for human medicine. It was fitted to a custom face mask in order to study the effect of an inhaled beta 2-agonist, fenoterol. Pulmonary function testing was performed on six horses following an acute exacerbation of heaves, characterized by tachypnea, wheezes, crackles, and spasmodic cough. Horses inhaled fenoterol in 1 mg increments administered as one 200 microgram puff every 5-10 s with the recording of data 5 min after the cessation of drug inhalation. A significant effect of fenoterol was shown for maximum change in transpulmonary pressure, dynamic compliance, lung resistance, and work of breathing, and the wheezes and crackles disappeared when auscultation was performed at the end of the test. This study demonstrates a novel, highly effective method for the rapid administration of inhaled medication in horses.
本研究的目的是使用一种为人类医学开发的紧凑型吸入装置，将定量吸入器产生的治疗性气雾剂给予出现气喘临床症状的马匹。该装置安装在定制的面罩上，以研究吸入性β2激动剂非诺特罗的效果。对6匹因气喘急性加重（表现为呼吸急促、喘息、湿啰音和痉挛性咳嗽）的马匹进行了肺功能测试。马匹以1毫克的增量吸入非诺特罗，每5 - 10秒吸入1次200微克的剂量，并在停止药物吸入5分钟后记录数据。结果显示，非诺特罗对跨肺压、动态顺应性、肺阻力和呼吸功的最大变化有显著影响，并且在测试结束时听诊时喘息和湿啰音消失。本研究证明了一种在马匹中快速给予吸入药物的新颖、高效方法。
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