甲氧苄啶-磺胺甲恶唑在淋球菌感染中的应用。
The use of trimethoprim-sulfamethoxazole in gonococcal infections.
作者信息
Austin T W, Holmes K K
出版信息
Can Med Assoc J. 1975 Jun 14;112(13 Spec No):37-9.
Abstract
In a multicentre trial of trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of uncomplicated gonococcal urethritis, optimal results were achieved with a regimen of six tablets once daily for 3 days. Treatment failure was found to be related significantly to the relative resistance to SMX of the pretreatment isolate. Further, the difference between therapeutic results from various geographic areas could be correlated with the relative sensitivity of pretreatment isolates to both SMX and TMP for that area. In view of these observations the role of TMP-SMX in the treatment of gonococcal disease is discussed.
摘要
在一项关于甲氧苄啶-磺胺甲恶唑（TMP-SMX）治疗单纯性淋菌性尿道炎的多中心试验中，每日一次服用六片、连服3天的治疗方案取得了最佳效果。研究发现，治疗失败与治疗前分离株对SMX的相对耐药性显著相关。此外，不同地理区域治疗结果的差异可能与该区域治疗前分离株对SMX和TMP的相对敏感性有关。鉴于这些观察结果，本文讨论了TMP-SMX在淋病治疗中的作用。
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