黑猩猩对淋球菌感染的获得性免疫和天然免疫。
Acquired and natural immunity to gonococcal infection in chimpanzees.
作者信息
Kraus S J, Brown W J, Arko R J
出版信息
J Clin Invest. 1975 Jun;55(6):1349-56. doi: 10.1172/JCI108054.
Abstract
Despite the fact that gonorrhea is our most common reportable infectious disease, little is known about natural and acquired resistance to Neisseria gonorrhoeae. With the chimpanzee model, which mimics human gonococcal infection in signs, symptoms, and host response, a natural resistance to gonococcal challenge was found. One aspect of this natural resistance became evident when the cervix and oral pharynx resisted more gonococci than the urethra. Natural resistance was also shown when environmental factors were found to influence resistance to gonococcal pharyngitis. In addition to natural resistance a postinfection-acquired immunity to the gonococcus was demonstrated. Following gonococcal pharyngitis, this anatomical location successfully resisted more gonococci than were initially resisted. Similarly, more gonococci were successfully resisted in rechallenging the urethra. These findings are related to the clinic situation and suggest possible new approaches to gonorrhea control.
摘要
尽管淋病是我们最常报告的传染病，但对于淋病奈瑟菌的天然耐药性和获得性耐药性知之甚少。利用在体征、症状和宿主反应方面模拟人类淋球菌感染的黑猩猩模型，发现了对淋球菌攻击的天然抵抗力。当宫颈和口咽部比尿道能抵抗更多的淋球菌时，这种天然抵抗力的一个方面就变得明显了。当发现环境因素会影响对淋菌性咽炎的抵抗力时，也显示出了天然抵抗力。除了天然抵抗力外，还证明了感染后对淋球菌获得的免疫力。在患淋菌性咽炎后，这个解剖部位成功抵抗的淋球菌比最初抵抗的更多。同样，在再次挑战尿道时，也成功抵抗了更多的淋球菌。这些发现与临床情况相关，并提示了控制淋病的可能新方法。
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