Girgis Michael M, Christodoulides Myron
Neisseria Research Group, Molecular Microbiology, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Pathogens. 2023 May 30;12(6):782. doi: 10.3390/pathogens12060782.
The history of research has involved the use of a wide variety of vertebrate and invertebrate animal models, from insects to humans. In this review, we itemise these models and describe how they have made significant contributions to understanding the pathophysiology of infections and to the development and testing of vaccines and antimicrobials. We also look ahead, briefly, to their potential replacement by complex in vitro cellular models.
研究历史涉及使用从昆虫到人类的各种各样的脊椎动物和无脊椎动物模型。在本综述中，我们列举了这些模型，并描述了它们如何为理解感染的病理生理学以及疫苗和抗菌药物的开发与测试做出了重大贡献。我们还简要展望了它们可能被复杂的体外细胞模型所取代的情况。
