Baranov A A, Nasonov E L, Shilkina N P, Samoriadova O G, Balabanova R M, Bimbazhapov R S
Ter Arkh. 1993;65(4):69-72.
The data are available on concentrations of Willebrand factor antigen (FVIII Ag) in 43 patients with rheumatoid arthritis (RA), 19 patients with livedo vasculitis (LV) and 56 donors. The measurements were made with solid-phase enzyme immunoassay. RA patients were found to display significantly higher concentrations of FVIII Ag (1.88 +/- 0.17 IU/ml) versus donors (1.06 +/- 0.05 IU/ml, p < 0.001) and LV patients (1.08 +/- 0.09 IU/ml, p < 0.001). No significant differences existed between FVIII Ag concentrations in LV patients and donors (p > 0.05). In 12 (28%) out of 43 RA patients FVIII Ag levels rose to 3 standard deviations from the mean in donors. Hyperproduction of FVIII Ag was associated with skin vasculitis symptoms in RA patients (p = 0.0004), more frequent occurrence of antinuclear factor (p = 0.02). Elevated concentrations of FVIII Ag did not relate to other extraarticular RA symptoms and general rheumatic inflammation, X-ray stage, RF titer, cryoglobulins, enhanced ESR, C-reactive protein.
现有43例类风湿关节炎（RA）患者、19例青斑样血管炎（LV）患者及56名献血者的血管性血友病因子抗原（FVIII Ag）浓度数据。采用固相酶免疫测定法进行测量。结果发现，RA患者的FVIII Ag浓度（1.88±0.17 IU/ml）显著高于献血者（1.06±0.05 IU/ml，p<0.001）和LV患者（1.08±0.09 IU/ml，p<0.001）。LV患者与献血者的FVIII Ag浓度之间无显著差异（p>0.05）。43例RA患者中有12例（28%）的FVIII Ag水平升至献血者均值的3个标准差以上。FVIII Ag的过度产生与RA患者的皮肤血管炎症状相关（p = 0.0004），抗核因子的出现频率更高（p = 0.02）。FVIII Ag浓度升高与其他关节外RA症状、全身性风湿性炎症、X线分期、RF滴度、冷球蛋白、ESR升高、C反应蛋白无关。
