Baranov A A, Shilkina N P, Nasonov E L, Beketova T B, Bokareva M I, Prokopenko A V, Bimbazhapov R M, Gorbacheva O V
Ter Arkh. 1993;65(5):15-9.
ELISA was used to investigate concentrations of Willebrand's factor antigen (WF III Ag) in 131 patients with various forms of systemic vasculitis (SV) and 93 patients with cardiovascular diseases. Compared to donors, a mean WF III Ag level proved significantly higher in all nosological variants of SV except periarteritis nodosa. Skin livedo vasculitis did not produce noticeable deviations in WF III Ag levels versus those in donors, whereas atherosclerosis obliterans showed these levels to be significantly elevated. Essential hypertension patients had low values of WF III Ag. The highest mean level of the antigen was found in rheumatoid vasculitis and Wegener's granulomatosis in which the antigen content rose to the highest for vascular affections levels (p < 0.05-0.01). High WF III Ag in Wegener's granulomatosis, periarteritis nodosa, leukocytoclastic vasculitis were indicative of renal involvement. Moreover, there was a tendency to an increase in the antigen quantities in Wegener's granulomatosis patients with intercurrent infections versus such without them. In other SV forms and atherosclerosis obliterans concentrations of the antigen were not related to clinical features of the disease.
采用酶联免疫吸附测定法（ELISA）检测了131例各种类型系统性血管炎（SV）患者和93例心血管疾病患者体内血管性血友病因子抗原（WF III Ag）的浓度。与供血者相比，除结节性多动脉炎外，SV所有病种的WF III Ag平均水平均显著升高。皮肤青斑样血管炎患者的WF III Ag水平与供血者相比无明显差异，而闭塞性动脉粥样硬化患者的该水平显著升高。原发性高血压患者的WF III Ag水平较低。类风湿性血管炎和韦格纳肉芽肿患者的抗原平均水平最高，其中抗原含量升至血管疾病中的最高水平（p<0.05 - 0.01）。韦格纳肉芽肿、结节性多动脉炎、白细胞破碎性血管炎患者的WF III Ag水平升高提示肾脏受累。此外，并发感染的韦格纳肉芽肿患者的抗原量有高于未并发感染患者的趋势。在其他SV类型和闭塞性动脉粥样硬化中，抗原浓度与疾病的临床特征无关。
