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[次氯酸钠在复苏后状态解毒治疗中的应用]

[Sodium hypochlorite in the detoxification therapy of postresuscitation states].

作者信息

Zaks I O, Bogoiavlenskiĭ I F, Martynov A K

出版信息

Anesteziol Reanimatol. 1994 Mar-Apr(2):22-4.

PMID:8059989
Abstract

The experiments on dogs recovered after a 10-min clinical death of acute blood loss have shown possible effective use of 300-500 mg/l sodium hypochlorite solution at a dose of 7-10 ml/kg for detoxication in the early postresuscitation period. A significant reduction in the level of toxemia within 3 hours of postresuscitation period, as compared to the control, promotes an increase in the percent of the animals survived and a more complete recovery of the neurological status. It has been shown in vitro than detoxication of lymph in septic patients was more effective using electrochemical oxidation, as compared to sorption on a carbon CKH sorbent, with lymph protein loss being significantly less. The technique of electrochemical liquid oxidation can be recommended as an alternative detoxicating technique in critical conditions.

摘要

对因急性失血临床死亡10分钟后复苏的狗进行的实验表明,在复苏后早期,以7-10毫升/千克的剂量使用300-500毫克/升的次氯酸钠溶液进行解毒可能有效。与对照组相比,复苏后3小时内毒血症水平显著降低,这促进了存活动物百分比的增加和神经状态的更完全恢复。体外实验表明,与碳CKH吸附剂吸附相比,电化学氧化对脓毒症患者的淋巴液解毒更有效,淋巴蛋白损失显著减少。电化学液体氧化技术可作为危急情况下的一种替代解毒技术推荐使用。

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