增殖性疣状白斑：诊断、管理及当前进展
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
作者信息
Capella Diogo Lenzi, Gonçalves Jussara Maria, Abrantes Adelino António Artur, Grando Liliane Janete, Daniel Filipe Ivan
机构信息
Universidade Federal de Santa Catarina (UFSC), Programa de Pós-graduação em Odontologia, Florianopolis, SC, Brazil.
Universidade Federal de Santa Catarina (UFSC), Departamento de Patologia, Florianopolis, SC, Brazil.
出版信息
Braz J Otorhinolaryngol. 2017 Sep-Oct;83(5):585-593. doi: 10.1016/j.bjorl.2016.12.005. Epub 2017 Jan 24.
INTRODUCTION
Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.
OBJECTIVE
To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update.
METHODS
A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized.
RESULTS
There are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate.
CONCLUSION
More research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.
引言
增殖性疣状白斑是一种口腔黏膜的多灶性、进行性病变，病因不明，通常对所有治疗尝试均有抵抗且频繁复发。其特征是口腔鳞状细胞癌和疣状癌转化的发生率很高。
目的
分析关于增殖性疣状白斑的研究并进行简要更新。
方法
在PubMed上进行检索，以识别对增殖性疣状白斑患者进行检查的研究（实验室研究、病例系列和文献综述）。
结果
文献中关于增殖性疣状白斑的研究不足。少数已发现的研究对其病因和诊断标准未达成共识。尽管已提出了几种治疗策略，但大多数仍显示出较高的复发率。
结论
有必要对增殖性疣状白斑进行更多研究，以了解和治疗这种疾病。
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