Best卵黄样黄斑营养不良患者的暗适应
Dark adaptation in patients with Best vitelliform macular dystrophy.
作者信息
Baca W, Fishman G A, Alexander K R, Glenn A M
机构信息
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
出版信息
Br J Ophthalmol. 1994 Jun;78(6):430-2. doi: 10.1136/bjo.78.6.430.
Psychophysical dark adaptation studies were performed in six patients with Best vitelliform macular dystrophy (BVMD) using a Goldmann-Weekers dark adaptometer. Prebleach thresholds were determined before obtaining a postbleach full recovery curve. Unlike patients with Stargardt macular dystrophy, all patients with BVMD showed a normal time to reach their baseline dark adapted thresholds after bleaching of their rod visual pigment when tested in clinically normal appearing retina. Although a lipofuscin material accumulates within retinal pigment epithelial cells in patients with either Best or Stargardt dystrophy, functional findings pertaining to recovery of rod dark adaptation thresholds as well as electro-oculogram light peak to dark trough ratios are different in these two disorders.
使用戈德曼-韦克斯暗适应计对6例Best卵黄样黄斑营养不良（BVMD）患者进行了心理物理学暗适应研究。在获得漂白后完全恢复曲线之前确定漂白前阈值。与Stargardt黄斑营养不良患者不同，所有BVMD患者在临床外观正常的视网膜中进行测试时，在其视杆视觉色素漂白后达到基线暗适应阈值的时间均正常。尽管Best或Stargardt营养不良患者的视网膜色素上皮细胞内都会积累脂褐素物质，但这两种疾病在视杆暗适应阈值恢复以及眼电图光峰与暗谷比值方面的功能表现有所不同。
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