Izumi K, Kitaura K, Chone Y, Tate H, Nakagawa T, Suzuki Y, Matsumoto K
Second Department of Pathology, University of Tokushima.
Jpn J Cancer Res. 1994 Jun;85(6):563-6. doi: 10.1111/j.1349-7006.1994.tb02396.x.
Neoplastic lesions of the kidneys in untreated Long-Evans Cinnamon (LEC) rats of 57-118 weeks old (85 males and 34 females) and male F344 rats of 64-93 weeks old (59 males) were examined histologically. The incidences of renal cell tumors in male and female LEC rats were 6/80 (8%) in weeks 57-65, 3/19 (16%) in weeks 66-75, 3/8 (38%) in weeks 76-105 and 7/12 (58%) in weeks 106-118. Of these tumors, 13 were microscopic adenomas and 7 were renal cell carcinomas. The copper content of the kidneys was about three times higher in LEC rats than in F344 rats (P < 0.001), but the iron content of the kidneys was similar in the two strains.
对57 - 118周龄未处理的长-伊文斯肉桂色（LEC）大鼠（85只雄性和34只雌性）以及64 - 93周龄的雄性F344大鼠（59只雄性）的肾脏肿瘤性病变进行了组织学检查。雄性和雌性LEC大鼠肾细胞肿瘤的发生率在57 - 65周为6/80（8%），66 - 75周为3/19（16%），76 - 105周为3/8（38%），106 - 118周为7/12（58%）。这些肿瘤中，13个为微小腺瘤，7个为肾细胞癌。LEC大鼠肾脏的铜含量比F344大鼠高约三倍（P < 0.001），但两品系大鼠肾脏的铁含量相似。
