从生姜（姜科植物）中分离抗鼻病毒倍半萜类化合物。
Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale).
作者信息
Denyer C V, Jackson P, Loakes D M, Ellis M R, Young D A
机构信息
Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, UK.
出版信息
J Nat Prod. 1994 May;57(5):658-62. doi: 10.1021/np50107a017.
The dried rhizomes of Indonesian ginger, Zingiber officinale, were investigated for antirhinoviral activity in the plaque reduction test. Fractionation by solvent extraction, solvent partition, and repeated chromatography guided by bioassay, allowed the isolation of several sesquiterpenes with antirhinoviral activity. The most active of these was beta-sesquiphellandrene [2] with an IC50 of 0.44 microM vs. rhinovirus IB in vitro.
对印尼姜（姜科植物姜）的干燥根茎进行了空斑减少试验，以研究其抗鼻病毒活性。通过溶剂萃取、溶剂分配和以生物测定为导向的反复色谱法进行分级分离，得以分离出几种具有抗鼻病毒活性的倍半萜。其中活性最强的是β-倍半水芹烯[2]，其对鼻病毒IB的体外半数抑制浓度（IC50）为0.44微摩尔。
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