Gilson S D, Withrow S J, Wheeler S L, Twedt D C
Comparative Oncology Unit, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins.
J Vet Intern Med. 1994 May-Jun;8(3):228-32. doi: 10.1111/j.1939-1676.1994.tb03222.x.
Fifty dogs with pheochromocytoma were identified in a retrospective study of a 9-year period. For 24 of 50 dogs (48%), the tumor was an incidental finding during necropsy or surgery. Presenting signs were referrable to the nervous system in 7 of the 26 symptomatic dogs (27%); were referrable to the cardiopulmonary system in 7 of 26 dogs (27%); or were nonspecific, reflecting general systemic disease, in 17 of 26 dogs (65%). Abnormal clinical findings were highly varied but were also generally referrable to the cardiopulmonary and nervous systems. Six of 7 dogs (86%) evaluated were hypertensive (systolic range, 164 to 325 mm Hg; diastolic range, 110 to 198 mm Hg). Serum biochemical findings were nonspecific, although 11 of 39 dogs (28%) were hypercholesterolemic. Abdominal fluid samples were analyzed in 6 dogs; 3 were nondiagnostic, and 3 were interpreted as lymphosarcoma. The imaging studies that were of most value included abdominal radiographs (mass identified in 9 of 16 dogs [56%]), caudal vena caval angiography (tumor thrombus correctly diagnosed in 4 of 7 dogs [57%]), and abdominal ultrasonography (mass seen in 5 of 6 dogs [83%] and tumor thrombus seen in 3 of 5 dogs [60%]). Local tumor invasion was present in 26 of 50 dogs (52%), regional lymph node metastases in 6 of 50 dogs (12%), and distant metastases in 12 of 50 dogs (24%). Cause of death was tumor-related in 19 of 50 dogs (38%) and non-tumor related in 28 of 50 dogs (54%).
在一项为期9年的回顾性研究中，共识别出50只患有嗜铬细胞瘤的犬。在50只犬中，有24只（48%）的肿瘤是在尸检或手术过程中偶然发现的。26只出现症状的犬中，7只（27%）的临床症状与神经系统有关；26只犬中，7只（27%）与心肺系统有关；26只犬中，17只（65%）症状不具特异性，反映的是全身性疾病。异常临床发现差异很大，但通常也与心肺和神经系统有关。接受评估的7只犬中有6只（86%）患有高血压（收缩压范围为164至325毫米汞柱；舒张压范围为110至198毫米汞柱）。血清生化检查结果不具特异性，尽管39只犬中有11只（28%）患有高胆固醇血症。对6只犬的腹腔积液样本进行了分析；3份样本未得出诊断结果，3份样本被诊断为淋巴肉瘤。最有价值的影像学检查包括腹部X光片（16只犬中有9只[56%]发现肿块）、尾腔静脉血管造影（7只犬中有4只[57%]正确诊断出肿瘤血栓）和腹部超声检查（6只犬中有5只[83%]发现肿块，5只犬中有3只[60%]发现肿瘤血栓）。50只犬中有26只（52%）存在局部肿瘤侵犯，50只犬中有6只（12%）出现区域淋巴结转移，50只犬中有12只（24%）发生远处转移。50只犬中有19只（38%）死于与肿瘤相关的原因，50只犬中有28只（54%）死于与肿瘤无关的原因。
