Barthez P Y, Marks S L, Woo J, Feldman E C, Matteucci M
Veterinary Medical Teaching Hospital, Davis, CA, USA.
J Vet Intern Med. 1997 Sep-Oct;11(5):272-8. doi: 10.1111/j.1939-1676.1997.tb00464.x.
This report presents the clinical, laboratory, imaging, and pathologic findings in 61 dogs with pheochromocytoma by retrospective evaluation of medical records. Pheochromocytomas were diagnosed by histopathologic examination of tissue specimens in all dogs. Special stains (chromogranin A and synaptophysin) also were used to confirm the chromaffin cell origin of the tumors. Epidemiologic findings were in agreement with previous studies, indicating that pheochromocytomas affect middle-aged to older dogs with no apparent gender or breed predilection. The tumor was considered clinical in 21 dogs (34%), was responsible for abnormalities related to a space-occupying mass in 7 dogs (11%), and was an incidental finding in 35 dogs (57%). The hematologic and biochemical findings were nonspecific. Hypertension was detected in 10 of 23 (43%) dogs tested, but all hypertensive dogs had concurrent diseases that may have contributed to hypertension. Abdominal ultrasonography was the most commonly used imaging procedure, with a mass detected in the region of the adrenal glands in 20 of 40 (50%) dogs examined. In 4 of the 20 dogs (20%), invasion of the caudal vena cava was identified. Surgery was performed in 17 dogs (28%) with immediate death or euthanasia of 5 dogs. Survival after surgery ranged from 1 day to 3.25 years. Pheochromocytomas were locally invasive in 39% of affected dogs and produced metastases in 13% of the cases. Common sites for metastases included regional lymph nodes, liver, lung, kidney, spleen, and bone. A high frequency of concurrent neoplasia (54%), including endocrine neoplasia, was identified.
本报告通过对病历的回顾性评估，呈现了61只患有嗜铬细胞瘤的犬的临床、实验室、影像学和病理检查结果。所有犬的嗜铬细胞瘤均通过组织标本的组织病理学检查确诊。还使用了特殊染色（嗜铬粒蛋白A和突触素）来确认肿瘤的嗜铬细胞起源。流行病学调查结果与先前的研究一致，表明嗜铬细胞瘤影响中年至老年犬，无明显的性别或品种倾向。21只犬（34%）的肿瘤具有临床症状，7只犬（11%）的肿瘤导致与占位性肿块相关的异常，35只犬（57%）的肿瘤为偶然发现。血液学和生化检查结果无特异性。在23只接受检测的犬中，有10只（43%）检测到高血压，但所有高血压犬都患有可能导致高血压的并发疾病。腹部超声检查是最常用的影像学检查方法，在40只接受检查的犬中，有20只（50%）在肾上腺区域检测到肿块。在这20只犬中，有4只（20%）发现尾腔静脉受侵。17只犬（28%）接受了手术，其中5只犬术后立即死亡或实施了安乐死。术后存活时间从1天到3.25年不等。39%的患犬嗜铬细胞瘤具有局部侵袭性，13%的病例发生转移。常见的转移部位包括区域淋巴结、肝脏、肺、肾脏、脾脏和骨骼。同时发现并发肿瘤的频率较高（54%），包括内分泌肿瘤。
