Lambert W, Van Bocxlaer J, Piette M, De Leenheer A
Laboratorium voor Toxicologie, Universiteit Gent, Belgium.
J Anal Toxicol. 1994 May-Jun;18(3):176-9. doi: 10.1093/jat/18.3.176.
A fatal case of trazodone and dothiepin self-poisoning is presented. A multi-technique approach (EMIT, TLC, HPLC/DAD, and GC/MS) allowed the unequivocal identification of trazodone and dothiepin as toxicologically relevant substances. Both compounds were quantitatively determined in a number of postmortem samples. Blood and urinary trazodone concentrations (28.7 and 90.5 micrograms/mL, respectively) and dothiepin concentrations (2.1 and 9.7 micrograms/mL, respectively) were far above therapeutic concentrations (i.e., 1.5 and 0.05 microgram/mL for trazodone and dothiepin, respectively, in blood) and were clearly the cause of death in this particular case. These data confirm the high toxicity and the high mortality rate in trazodone intoxications, especially when co-ingestion of other substances is involved.
本文报告了一例曲唑酮和多塞平自服中毒致死的病例。采用多种技术方法（酶放大免疫分析技术、薄层色谱法、高效液相色谱/二极管阵列检测法和气相色谱/质谱联用法）明确鉴定出曲唑酮和多塞平为具有毒理学相关性的物质。在多个尸检样本中对这两种化合物进行了定量测定。血液和尿液中的曲唑酮浓度（分别为28.7和90.5微克/毫升）以及多塞平浓度（分别为2.1和9.7微克/毫升）远高于治疗浓度（即血液中曲唑酮和多塞平的治疗浓度分别为1.5和0.05微克/毫升），在该特定病例中显然是致死原因。这些数据证实了曲唑酮中毒的高毒性和高死亡率，尤其是在涉及同时摄入其他物质的情况下。
