Cancrini G, Tassi P, Coluzzi M
Institute of Parasitology, University of Rome La Sapienza.
Parassitologia. 1989 Aug-Dec;31(2-3):177-82.
The prophylactic efficacy of ivermectin against Dirofilaria repens infections in dogs was investigated. A first trial was carried out on 15 dogs exposed to four inoculations of L3 larvae at 15-day intervals and treated, in groups of five, with 0, 6 or 12 micrograms/kg body weight of ivermectin given per os 30 and 60 days after the first inoculation. Necropsy, performed about 9 months later, revealed that worm burdens were reduced by 86.6 and 92.8% for the 6 and 12 micrograms/kg dose levels, respectively. In a second trial with an otherwise identical protocol, a dose rate of 24 micrograms/kg of ivermectin was tested in 12 dogs. Only one of the six treated dogs was found worm free at necropsy. The worm burden was reduced by 87.9% in treated animals as opposed to controls. A lengthening of the prepatent periods, which might be considered dose related, was apparent in all treated groups. Ivermectin was not completely effective in preventing establishment of experimental infections with D. repens in dogs.
研究了伊维菌素对犬恶丝虫感染的预防效果。首次试验对15只犬进行，每隔15天对其接种4次L3幼虫，并在首次接种后30天和60天，将其分成每组5只的小组，分别口服给予0、6或12微克/千克体重的伊维菌素。约9个月后进行尸检，结果显示，6微克/千克和12微克/千克剂量组的虫负荷分别降低了86.6%和92.8%。在另一项采用相同方案的试验中，对12只犬测试了24微克/千克的伊维菌素剂量率。尸检时发现，6只接受治疗的犬中只有1只未感染蠕虫。与对照组相比，治疗组动物的虫负荷降低了87.9%。在所有治疗组中，均明显出现了与剂量相关的潜伏期延长现象。伊维菌素在预防犬感染匐行恶丝虫方面并非完全有效。
