Baumheuer M E, Zerfass M, Ruppel A, Leichsenring M
Division of Tropical Pediatrics, University Children's Hospital, Heidelberg, Germany.
Trop Med Parasitol. 1994 Mar;45(1):5-8.
The fatty acid status of mice six weeks after infection with Schistosoma mansoni was investigated and compared with the status of uninfected mice. Fatty acids of several plasma and erythrocyte lipid fractions were determined by capillary gas-chromatography. Major fatty acids including linoleic acid, arachidonic acid and dihomo-gamma-linolenic acid, were significantly reduced in the plasma phospholipids of infected mice. Arachidonic acid was also reduced in plasma cholesterolesters. The degree of the plasma arachidonic acid reduction in infected animals correlated neither with the worm load nor with the liver weight. The plasma fatty acid changes were not reflected in the lipids of the red blood cells. Since the observed changes in the plasma fatty acid composition occurred early after infection, they are unlikely to be a consequence of portal hypertension. It is speculated that an activation of the eicosanoid metabolism may contribute to these changes.
研究了感染曼氏血吸虫六周后小鼠的脂肪酸状态，并与未感染小鼠的状态进行比较。通过毛细管气相色谱法测定了几种血浆和红细胞脂质组分中的脂肪酸。感染小鼠血浆磷脂中的主要脂肪酸，包括亚油酸、花生四烯酸和二高-γ-亚麻酸，显著减少。血浆胆固醇酯中的花生四烯酸也减少。感染动物血浆花生四烯酸减少的程度与虫负荷和肝脏重量均无相关性。血浆脂肪酸变化未反映在红细胞脂质中。由于观察到的血浆脂肪酸组成变化在感染后早期就已出现，它们不太可能是门静脉高压的结果。据推测，类花生酸代谢的激活可能导致了这些变化。
