Tilvis R S, Miettinen T A
J Clin Endocrinol Metab. 1985 Oct;61(4):741-5. doi: 10.1210/jcem-61-4-741.
The fatty acid composition of serum lipids, erythrocytes, platelets, and diet was studied in women with insulin-dependent diabetes (IDDM) and in normal subjects matched for age, sex, body weight, and serum lipid levels. The dietary intake of linoleic acid was higher in IDDM patients than in the normal subjects. The linoleic acid content of serum triglycerides, cholesterol esters, and phospholipids and of red cells and platelets were elevated in patients with IDDM proportionately to their dietary linoleate intake. The linoleic acid content of serum lipids, but not of diet, was significantly correlated with glycosylated hemoglobin A1c in IDDM patients. However, the serum lipid content of arachidonic acid and other n-6 polyunsaturated fatty acids, which are metabolites of linoleic acid, was decreased in IDDM patients, but these metabolites were normal or increased in their cell membranes. The contents of n-3 polyunsaturated fatty acids were decreased in serum and platelet lipids and tended to be increased in erythrocyte membranes of diabetic patients. The results suggest that elongation and desaturation of essential fatty acids, linoleic acid in particular, are decreased in women with IDDM.
对胰岛素依赖型糖尿病（IDDM）女性患者以及年龄、性别、体重和血脂水平相匹配的正常受试者的血清脂质、红细胞、血小板和饮食中的脂肪酸组成进行了研究。IDDM患者的亚油酸饮食摄入量高于正常受试者。IDDM患者血清甘油三酯、胆固醇酯、磷脂以及红细胞和血小板中的亚油酸含量与其饮食中亚油酸酯摄入量成比例升高。IDDM患者血清脂质而非饮食中的亚油酸含量与糖化血红蛋白A1c显著相关。然而，IDDM患者血清脂质中花生四烯酸和其他n-6多不饱和脂肪酸（亚油酸的代谢产物）的含量降低，但这些代谢产物在其细胞膜中正常或增加。糖尿病患者血清和血小板脂质中的n-3多不饱和脂肪酸含量降低，而红细胞膜中的n-3多不饱和脂肪酸含量则有增加趋势。结果表明，IDDM女性患者中必需脂肪酸尤其是亚油酸的延长和去饱和作用降低。
