Cheeke P R
Department of Animal Sciences, Oregon State University, Corvallis 97331-6702.
Vet Hum Toxicol. 1994 Jun;36(3):240-7.
Coevolutionary relationships between herbivores and poisonous plants are described. Hepatic detoxification reactions (Phase I and Phase II) are discussed in the context of susceptibility and resistance to poisonous plants. Animal species differences in susceptibility to poisonous plants are discussed, with a comparison of liver vs rumen microbe detoxification pathways. It is concluded, especially with regard to pyrrolizidine alkaloids, that species differences are due to differences in hepatic metabolism rather than to rumen microbes. Linkages between hepatic detoxification abilities and feeding behavior are proposed, as an evolutionary strategy allowing animals resistant to particular toxins to evolve feeding responses to exploit food resources containing toxins to which the animal is resistant.
描述了食草动物与有毒植物之间的协同进化关系。在对有毒植物的易感性和抗性背景下讨论了肝脏解毒反应（I 期和 II 期）。讨论了动物物种对有毒植物易感性的差异，并比较了肝脏与瘤胃微生物的解毒途径。得出的结论是，特别是对于吡咯里西啶生物碱，物种差异是由于肝脏代谢的差异而非瘤胃微生物。提出了肝脏解毒能力与摄食行为之间的联系，作为一种进化策略，使对特定毒素具有抗性的动物能够进化出摄食反应，以利用含有该动物具有抗性的毒素的食物资源。
