Jackson J A, Petersen S A, Wailoo M P
Department of Pre-Clinical Sciences and Child Health, University of Leicester.
Arch Dis Child. 1994 Jul;71(1):80-3. doi: 10.1136/adc.71.1.80.
This study aimed to examine the overnight temperature pattern of babies during the prodromal phase of minor illnesses. The overnight rectal temperature pattern of 123 babies was recorded weekly from about 6 to at least 16 weeks old, while parents maintained detailed records of signs of illness. By analysis of patterns of signs and visits to the general practitioner, 86 periods of minor illness were identified, mostly upper respiratory tract infections, though it was not usually possible to identify the infection by conventional virology. Data were analysed separately for babies who had developed an adult-like night time temperature pattern and those who had not. In both groups, obvious signs of illness were preceded by a disturbance of night time temperature pattern. Temperature was significantly raised over control weeks, though few babies were clinically febrile. The greatest temperature disturbances were seen in the three days before illness, though some disturbances were seen up to seven days before. A similar disturbance of temperature was seen the night after diphtheria, pertussis, and tetanus immunisation, and individual responses to natural infection and immunisation were well correlated, suggesting that the temperature change is more a function of the host response than the infecting agent.
本研究旨在检测婴儿在轻症前驱期的夜间体温模式。从约6周龄至至少16周龄，每周记录123名婴儿的夜间直肠体温模式，同时家长详细记录疾病症状。通过分析症状模式以及看全科医生的就诊情况，确定了86个轻症阶段，大多数为上呼吸道感染，不过通常无法通过传统病毒学方法确定感染源。对已形成类似成人夜间体温模式的婴儿和未形成该模式的婴儿的数据分别进行了分析。在两组中，疾病的明显症状出现之前夜间体温模式均有紊乱。与对照周相比，体温显著升高，不过临床上发热的婴儿很少。体温干扰最大出现在发病前三天，不过在发病前七天内也有一些干扰情况。在白喉、百日咳和破伤风免疫接种后的当晚也出现了类似的体温干扰，个体对自然感染和免疫接种的反应具有良好的相关性，这表明体温变化更多是宿主反应的作用，而非感染因子的作用。
